...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Physiology and Biochemistry >Coreopsis Tinctoria Modulates Lipid Metabolism by Decreasing Low-Density Lipoprotein and Improving Gut Microbiota
【24h】

Coreopsis Tinctoria Modulates Lipid Metabolism by Decreasing Low-Density Lipoprotein and Improving Gut Microbiota

机译：金鸡菊通过减少低密度脂蛋白和改善肠道菌群来调节脂质代谢

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/Aims The prevalence of hyperlipidemia is increasing rapidly. The role of Coreopsis tinctoria (CT) in amending lipid metabolism in hyperlipidemia patients has not been reported. This study aims to evaluate the role of CT in altering lipid metabolism in hyperlipidemia patients and to explore the possible mechanisms mediated by gut microbiota in hyperlipidemia mice models. Methods A retrospective analysis in 40 hyperlipidemia patients was conducted, in which 20 patients took fenofibrate and another 20 patients normatively drank water with CT. Hyperlipidemia mice models were also established. Blood biochemical tests were performed using an automatic biochemical analyzer. Liver histopathology was observed by hematoxylin and eosin staining. Ileocecal samples were collected from mice, and bacterial DNA was extracted and sequenced by MiSeq sequencing. Bacterial composition and differences were analyzed. Results In hyperlipidemia patients, CT was associated with decreased triglyceride and low-density lipoprotein (LDL) levels without liver injury. The experimental hyperlipidemia model also verified a similar result. Gut microbial richness and diversity were significantly decreased in hyperlipidemic mice, but increased after CT treatment. Bacterial communities were significantly differentiated between normal controls and hyperlipidemic mice. CT administration improved gut microbiota composition to an approximately normal status. Meanwhile, CT administration attenuated bacterial alterations at the class, order, family, and genus levels in hyperlipidemic mice. Importantly, the genera Barnesiella, Lactobacillus, and Helicobacter achieved high discriminatory power in hyperlipidemic mice relative to normal controls. Conclusions CT can modulate blood lipid metabolism with improvement of liver function by decreasing LDL and improving gut microbiota compositions. These findings may provide novel therapeutic strategies for patients with hyperlipidemia.
机译：背景/目的高脂血症的发生率正在迅速增加。尚未报道金丝雀（CT）在高脂血症患者中改善脂质代谢的作用。这项研究旨在评估CT在改变高脂血症患者脂质代谢中的作用，并探讨高脂血症小鼠模型中肠道菌群介导的可能机制。方法对40例高脂血症患者进行回顾性分析，其中20例患者服用非诺贝特，另20例患者按标准喝水。还建立了高脂血症小鼠模型。使用自动生化分析仪进行血液生化测试。通过苏木精和曙红染色观察肝组织病理学。从小鼠收集冰盲样品，并提取细菌DNA，并通过MiSeq测序进行测序。分析细菌组成和差异。结果在高脂血症患者中，CT与甘油三酯降低和低密度脂蛋白（LDL）水平降低相关，而无肝损伤。实验性高脂血症模型也证实了相似的结果。高脂血症小鼠的肠道微生物丰富度和多样性显着降低，但经CT治疗后增加。正常对照组和高脂血症小鼠之间的细菌群落明显不同。 CT给药可将肠道菌群组成提高到大致正常状态。同时，CT给药减弱了高脂血症小鼠的细菌分类，顺序，家族和属水平的改变。重要的是，与高脂血症小鼠相比，Barnesiella，Lactobacillus和Helicobacter属具有较高的歧视能力。结论CT可通过降低LDL和改善肠道菌群组成来调节血脂代谢，改善肝功能。这些发现可能为高脂血症患者提供新颖的治疗策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号