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Chemotherapy with low-dose capecitabine as palliative treatment in a patient with metastatic breast cancer: a case report

机译：低剂量卡培他滨化疗作为转移性乳腺癌患者的姑息治疗：一例报告

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摘要

Chemotherapeutic agents are rarely used for symptom management in patients under palliative care setting. This is because chemotherapeutic agents not only have limited efficacy in palliative treatment but are also known to exert severe adverse effects. We describe our experience with a patient with metastatic breast cancer who was successfully treated with low-dose capecitabine, without the development of any severe toxicities and with significant improvement in activities of daily living (ADL) and quality of life (QOL). The patient, a 43-year-old female, had breast cancer with liver, bone, and cutaneous metastases. She visited our clinic after a year-long hiatus during which she underwent alternative therapy. She presented with ulcerated lesions on the anterior chest and dyspnea due to malignant pleural effusion. After treatment for the latter, we administered capecitabine (600 mg/day) in accordance with the wishes of the patient and her attendants. The ulcerated lesions on the anterior chest, dyspnea, ADL and QOL improved significantly, without the development of any serious adverse effects. The findings of this case indicate that chemotherapy in the form of low-dose capecitabine monotherapy may be considered in patients under palliative care setting.
机译：在姑息治疗环境下，化学治疗药物很少用于症状管理。这是因为化学治疗剂不仅在姑息治疗中具有有限的功效，而且还已知会产生严重的副作用。我们描述了在转移性乳腺癌患者中的经验，该患者已成功用小剂量卡培他滨治疗，没有出现任何严重的毒性反应，并且日常生活活动（ADL）和生活质量（QOL）均得到显着改善。该患者是一名43岁的女性，患有乳腺癌，并伴有肝，骨和皮肤转移。在长达一年的休假之后，她去了我们的诊所，期间她接受了替代疗法。由于恶性胸腔积液，她出现了前胸溃疡性呼吸困难和呼吸困难。后者治疗后，我们根据患者及其护理人员的意愿服用卡培他滨（600毫克/天）。前胸，呼吸困难，ADL和QOL的溃疡性病变明显改善，而未出现任何严重的不良反应。该病例的发现表明，在姑息治疗情况下，可考虑采用小剂量卡培他滨单药形式的化学疗法。

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