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首页> 外文期刊>Cases Journal >Plantar erythrodysesthesia with bullous otitis externa, toxicities from sorafenib: a case report
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Plantar erythrodysesthesia with bullous otitis externa, toxicities from sorafenib: a case report

机译：足底红斑合并大疱性外耳道炎，索拉非尼产生的毒性：一例报告

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摘要

Lung cancer is the leading cause of cancer death worldwide and the use of novel agents, such as sorafenib has now demonstrated activity in Non Small Cell Lung Cancer. We present a case of a 77-year-old Caucasian male with advanced adenocarcinoma of the lung, who was being treated on clinical trial with single agent sorafenib. After seven weeks of treatment the patient presented to clinic with difficulty walking. Physical exam revealed acral erythema with bollous formation on bilateral soles of his feet. Otoscopic exam revealed bilateral external canal bullous lesion. The patient was diagnosed with plantar erythrodysesthesia with bullous otitis externa, a new toxicities in patients being treated with sorafenib.
机译：肺癌是全球癌症死亡的主要原因，使用新型药物（如索拉非尼）现已证明在非小细胞肺癌中具有活性。我们介绍了一例77岁的白人男性，患有晚期肺腺癌，正在接受单药索拉非尼的临床试验治疗。经过七个星期的治疗，患者步行困难就诊。体格检查发现他的双侧脚掌上有痤疮形成的红斑。耳镜检查发现双侧外管大疱性病变。该患者被诊断患有足底红斑外翻大疱性耳炎，这对索拉非尼治疗的患者具有新的毒性。

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