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首页> 外文期刊>Case Reports in Genetics >Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis
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Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis

机译：三体综合征11作为儿童急性早幼粒细胞白血病预后不良的附加染色体改变

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The prognostic significance of the additional abnormalities to the t(15; 17) remains controversial. We report a case of promyelocytic leukemia (APL) in a ten-year-old boy. Classical and molecular cytogenetic (FISH) studies of a bone marrow sample obtained at diagnosis revealed the presence of trisomy of chromosome 11 as an additional chromosomal abnormality to the t(15; 17). The presence of the translocation t(15; 17), the cytogenetic marker of APL, is usually associated with good response to treatment with ATRA. In this case, although the patient had risk factors associated with good prognosis, he evolved and died quickly. So it seems that the presence of the trisomy 11 may be associated with disease progression and the poor outcome. To our knowledge, this is the first reported case of t(15; 17) associated with trisomy of chromosome 11 in a child with APL.
机译：t（15; 17）的其他异常的预后意义仍然存在争议。我们报告了一个十岁男孩的早幼粒细胞白血病（APL）病例。在诊断时获得的骨髓样本的经典和分子细胞遗传学（FISH）研究表明，存在11号染色体三体性染色体，这是t（15; 17）的另一种染色体异常。易位t（15; 17）是APL的细胞遗传学标记，通常与对ATRA治疗的良好反应相关。在这种情况下，尽管患者具有与良好预后相关的危险因素，但他仍在进化并迅速死亡。因此看来，三体性11的存在可能与疾病进展和不良预后有关。据我们所知，这是第一例报道的t（15; 17）与APL患儿11号染色体三体性相关的病例。

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