Cationic Antimicrobial Peptides (AMPs): Thermodynamic Characterization of Peptide–Lipid Interactions and Biological Efficacy of Surface‐Tethered Peptides

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Cationic Antimicrobial Peptides (AMPs): Thermodynamic Characterization of Peptide–Lipid Interactions and Biological Efficacy of Surface‐Tethered Peptides

机译：阳离子抗菌肽（AMPs）：肽-脂质相互作用的热力学表征和表面束缚肽的生物功效

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AbstractAntimicrobial peptides (AMPs) were investigated both as novel antibiotics and as antimicrobial coatings for biomedical implants. The hydrophobicity, conformational constraint, and strong binding of cyclo-RRRWFW (c-WFW) to the O-antigen region of lipopolysaccharide (LPS) were identified as important features for potent anti-E. coli activity. Furthermore, tethered membrane-active AMPs with uniform distribution of cationic and hydrophobic amino acid residue were identified as good anti-biofilm agents.

机译：摘要研究了抗菌肽（AMPs）作为新型抗生素和生物医学植入物的抗菌涂层。疏水性，构象约束，和环状RRRWFW（c-WFW）与脂多糖（LPS）的O抗原区域的牢固结合被确定为有效的抗E的重要特征。大肠杆菌活性。此外，具有均匀分布的阳离子和疏水氨基酸残基的束缚膜活性AMP被确定为良好的抗生物膜剂。

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《ChemistryOpen》 |2015年第3期|共5页
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中图分类生物物理学;
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1. The Use of Tethered Bilayer Lipid Membranes to Identify the Mechanisms of Antimicrobial Peptide Interactions with Lipid Bilayers [J] . Amani Alghalayini, Alvaro Garcia, Thomas Berry, Antibiotics . 2019,第1期

机译：系留双层脂质膜的使用，以识别与脂质双层的抗菌肽相互作用的机制。
2. In vitro characterization of human peptide transporter hPEPT1 interactions and passive permeation studies of short cationic antimicrobial peptides [J] . Flaten G.E., Kottra G., Stensen W., Journal of Medicinal Chemistry . 2011,第7期

机译：人肽转运蛋白hPEPT1相互作用的体外表征和短阳离子抗菌肽的被动渗透研究
3. Mode of Action of Cationic Antimicrobial Peptides Defines the Tethering Position and the Efficacy of Biocidal Surfaces [J] . Mojtaba Bagheri, Michael Beyermann, Margitta Dathe Bioconjugate Chemistry . 2012,第1期

机译：阳离子抗菌肽的作用方式定义了束缚位置和杀菌表面的功效
4. Effects of net charge and the number of positively charged residues on the biological activity of amphipathic α-helical cationic antimicrobial peptides [C] . Ziqing Jiang, Adriana I. Vasil, John Hale American Peptide Symposium . 2009

机译：净电荷的影响和带正电荷残留量对两亲性α-螺旋阳离子抗菌肽的生物活性的影响
5. Investigation of the peptide-lipid interactions of a beta -hairpin antimicrobial peptide using solid-state NMR [D] . Mani, Rajeswari 2007

机译：使用固态NMR研究β-发夹抗菌肽的肽-脂相互作用
6. Cationic Antimicrobial Peptides (AMPs): Thermodynamic Characterization of Peptide–Lipid Interactions and Biological Efficacy of Surface-Tethered Peptides [O] . Dr. Mojtaba Bagheri 2015

机译：阳离子抗菌肽（AMPs）：肽-脂质相互作用的热力学表征和表面束缚肽的生物功效
7. Characterization of Antimicrobial Peptide Insertion in Tethered Bilayer Lipid Membranes by Pulse Amperometry and Linear Sweep Voltammetry Methods [O] . Cranfield Charles G., Cornell Bruce, Grage Stephan L., 2013

机译：用脉冲安培法和线性扫描伏安法表征双链脂质膜中抗菌肽的插入

Cationic Antimicrobial Peptides (AMPs): Thermodynamic Characterization of Peptide–Lipid Interactions and Biological Efficacy of Surface‐Tethered Peptides

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