Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance

RitaNahta

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Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance

机译：解读胰岛素样生长因子-I受体在曲妥珠单抗中的作用

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Resistance to the HER2-targeted antibody trastuzumab is a major clinical concern in the treatment of HER2-overexpressing metastatic breast cancer. Increased expression or signaling of the insulin-like growth factor-I receptor (IGF-IR) has been reported in a subset of cell lines and clinical samples derived from trastuzumab-resistant breast cancers. Genetic and pharmacologic inhibition of IGF-IR signaling has been shown to improve response to trastuzumab in trastuzumab-naïve and trastuzumab-resistant models. In this paper, we will discuss the role of IGF-IR signaling in trastuzumab resistance. Further, we will discuss cotargeting IGF-IR and HER2 as a potential therapeutic strategy for HER2-over-expressing breast cancers that have progressed on trastuzumab treatment.

机译：对靶向HER2的抗体曲妥珠单抗的耐药性是治疗HER2过表达的转移性乳腺癌的主要临床关注点。胰岛素样生长因子-I受体（IGF-1R）的表达或信号转导已在抗曲妥珠单抗的乳腺癌细胞系和临床样品中得到了报道。在未经曲妥珠单抗和曲妥珠单抗的模型中，IGF-1R信号的遗传和药理抑制作用已显示可改善对曲妥珠单抗的反应。在本文中，我们将讨论IGF-1R信号在曲妥珠单抗耐药中的作用。此外，我们将讨论共同靶向IGF-1R和HER2作为在曲妥珠单抗治疗上取得进展的HER2过表达乳腺癌的潜在治疗策略。

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《Chemotherapy Research and Practice》 |2012年第1期|共7页
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RitaNahta;
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1. A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. [J] . Ji QS, Mulvihill MJ, Rosenfeld-Franklin M, Molecular cancer therapeutics . 2007,第8期

机译：一种新颖的，有效的和选择性的胰岛素样生长因子-1受体激酶抑制剂在体外阻断胰岛素样生长因子-1受体信号传导，并在体内抑制胰岛素样生长因子-1受体依赖性肿瘤的生长。
2. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). [J] . Lu Y, Zi X, Zhao Y, Journal of the National Cancer Institute . 2001,第24期

机译：胰岛素样生长因子-I受体信号传导和对曲妥珠单抗（赫赛汀）的抗性。
3. Effects of implants of trenbolone acetate, estradiol, or both, on muscle insulin-like growth factor-I, insulin-like growth factor-I receptor, estrogen receptor-{alpha}, and androgen receptor messenger ribonucleic acid levels in feedlot steers [J] . Pampusch MS, White ME, Hathaway MR, Journal of Animal Science . 2008,第12期

机译：醋酸群勃龙和/或雌二醇植入物对肥育肉牛肌肉中胰岛素样生长因子-I，胰岛素样生长因子-I受体，雌激素受体-α和雄激素受体信使核糖核酸水平的影响
4. Changes in the growth hormone/insulin-like growth factor-I axis during the early postnatal development of Tibet piglets (a typical mini pig) [C] . Q.Hu, M.J.Bo, P.Kang, Progress in functional amino acids and carbohydrates for animal production . 2009

机译：西藏仔猪（典型小型仔猪）出生后早期生长激素/胰岛素样生长因子-I轴的变化
5. The role of the insulin-like growth factor-I receptor in the tumor microenvironment and in the radiation response pathway regulated by ATM. [D] . Peretz, Shani. 2001

机译：胰岛素样生长因子-I受体在肿瘤微环境和由ATM调节的放射反应途径中的作用。
6. Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance [O] . Rita Nahta 2012

机译：解读胰岛素样生长因子-I受体在曲妥珠单抗中的作用
7. Insulin-like Growth Factor-I Receptor/Human Epidermal Growth Factor Receptor 2 Heterodimerization Contributes to Trastuzumab Resistance of Breast Cancer Cells [O] . Rita Nahta, Linda X.H. Yuan, Bing Zhang, 2005

机译：胰岛素样生长因子-I受体/人表皮生长因子受体2异二聚化有助于乳腺癌细胞的曲据

Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance

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