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Eight unique basal bodies in the multi-flagellated diplomonad Giardia lamblia

机译：鞭毛双鞭毛贾第鞭毛虫中的八个独特基体

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摘要

Giardia lamblia is an intestinal parasitic protist that causes significant acute and chronic diarrheal disease worldwide. Giardia belongs to the diplomonads, a group of protists in the supergroup Excavata. Diplomonads are characterized by eight motile flagella organized into four bilaterally symmetric pairs. Each of the eight Giardia axonemes has a long cytoplasmic region that extends from the centrally located basal body before exiting the cell body as a membrane-bound flagellum. Each basal body is thus unique in its cytological position and its association with different cytoskeletal features, including the ventral disc, axonemes, and extra-axonemal structures. Inheritance of these unique and complex cytoskeletal elements is maintained through basal body migration, duplication, maturation, and their subsequent association with specific spindle poles during cell division. Due to the complex composition and inheritance of specific basal bodies and their associated structures, Giardia may require novel basal body-associated proteins. Thus, protists such as Giardia may represent an undiscovered source of novel basal body-associated proteins. The development of new tools that make Giardia genetically tractable will enable the composition, structure, and function of the eight basal bodies to be more thoroughly explored.
机译：贾第鞭毛虫是一种肠道寄生虫，在世界范围内引起严重的急性和慢性腹泻病。贾第鞭毛虫属于双足动物，双足动物是超群Excavata中的一组原生生物。 Diplomonads的特征是将八个活动鞭毛组织成四个双边对称对。八个贾第鞭毛虫轴突中的每一个都有一个长的胞质区域，该区域从位于中心的基体开始延伸，然后以膜结合鞭毛形式离开细胞体。因此，每个基体在细胞学位置以及与不同细胞骨架特征（包括腹盘，轴突和轴突外结构）的关联方面都是独特的。这些独特而复杂的细胞骨架元素的遗传是通过基底体迁移，复制，成熟及其随后在细胞分裂过程中与特定纺锤体极的关联来维持的。由于特定基体及其相关结构的复杂组成和遗传，贾第鞭毛虫可能需要新颖的基体相关蛋白。因此，诸如贾第虫（Giardia）之类的生物可能代表了新发现的与基础身体相关的蛋白质。开发使贾第虫具有遗传易处理性的新工具将使八个基体的组成，结构和功能得到更彻底的探索。

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