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首页> 外文期刊>Circulation journal >Impact of Weight Change Since Age 20 and Cardiovascular Disease Mortality Risk – The Ohsaki Cohort Study –
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Impact of Weight Change Since Age 20 and Cardiovascular Disease Mortality Risk – The Ohsaki Cohort Study –

机译：Ohsaki队列研究– 20岁以来体重变化的影响和心血管疾病的死亡率风险

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Background: ?It is unclear whether weight change since young adulthood affects the risk of mortality due to cardiovascular disease (CVD). The aim of this study was to investigate weight change since age 20 in relation to the risk of CVD mortality. Methods and Results: ?A total of 41,364 eligible Japanese men and women aged 40–79 years participated in the Ohsaki Cohort Study baseline survey in 1994. Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD mortality were calculated according to weight change since age 20 (loss ≥10.0kg; loss 5.0?9.9kg; stable [±4.9 kg]; gain 5.0?9.9kg; gain ≥10.0kg). During 13.3 years of follow-up, 1,756 participants died of CVD. The association between weight change and CVD mortality was L-shaped in men and U-shaped in women; the multivariate HR (95% CI) for men with weight loss ≥10.0kg was 1.52 (1.25–1.85), and that for women with weight loss ≥10.0kg and weight gain ≥10.0kg was 1.62 (1.25–2.11) and 1.36 (1.09–1.69), respectively. Cross-classification analysis based on body mass index (BMI) at age 20 and weight change tended to be U-shaped, except for men whose BMI had been 2 at age 20, in which case it was L-shaped. Conclusions: ?Weight loss since young adulthood is associated with excess risk of mortality due to CVD in men, while a U-shaped relationship was observed for women.??( Circ J ?2013; 77 : 679–686)
机译：背景：不清楚自成年后体重增加是否会影响心血管疾病（CVD）的死亡风险。这项研究的目的是研究20岁以来体重变化与CVD死亡风险的关系。方法和结果：1994年，总共41,364名40-79岁的日本男女参加了Ohsaki队列研究基线调查。根据以下方法计算出CVD死亡率的危险比（HR）和95％置信区间（CI）。自20岁起体重发生变化（体重减轻≥10.0kg;体重减轻5.0-9.9kg;稳定[±4.9 kg];体重增加5.0-9.9kg;体重≥10.0kg）。在13.3年的随访中，有1,756名参与者死于CVD。体重变化与CVD死亡率之间的关系在男性中为L型，在女性中为U型。体重≥10.0kg的男性的多元HR（95％CI）为1.52（1.25–1.85），体重≥10.0kg和体重≥10.0kg的女性的HR为1.62（1.25–2.11）和1.36（ 1.09–1.69）。基于20岁时体重指数（BMI）和体重变化的交叉分类分析趋于呈U型，但20岁时BMI为2的男性则为L型。结论：？男性成年后体重减轻与男性因CVD造成的死亡风险过高有关，而女性则呈U型关系。（Circ J，2013; 77：679–686）。

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