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首页> 外文期刊>Circulation journal >Cytokine Genetic Polymorphisms and Susceptibility to Kawasaki Disease in Taiwanese Children
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Cytokine Genetic Polymorphisms and Susceptibility to Kawasaki Disease in Taiwanese Children

机译：台湾儿童细胞因子遗传多态性与川崎病易感性

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Background: ?The relationship between cytokine gene polymorphisms and susceptibility to Kawasaki diseases (KD) is still controversial, so the aim of the present study was to investigate the association of 14 various polymorphisms of 9 cytokine genes (interleukin (IL)-1A, IL-1B, IL-1RN, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-A and transforming growth factor-B) with KD risk. Methods and Results: ?A total of 211 KD children and 221 adult controls were recruited. All controls were frequency matched to KD patients on sex and ethnicity. PCR and TaqMan assays were used for genotyping. There were no significant differences between KD children and adult controls in the genotype or allelic type frequencies of the 14 polymorphisms. No significant associations were found between haplotypes, constructed by IL-1B, IL-4, IL-8, and IL-10 cytokine genes, and risk of KD. Additionally, a linear trend was observed when these single nucleotide polymorphisms were combined, as evidenced by an increasing risk of KD as the number of at-risk genotypes increased (Plinear trend=0.002). In the stratification analysis of age and sex, there was a linear trend of KD risk as the number of at-risk genotypes increased among those aged >12 months (P=0.014) or female (P=0.001), respectively. Conclusions: ?No associations between individual cytokine genetic polymorphisms and susceptibility of KD were observed, but a gene-dosage effect on the risk of KD was found, especially for older or female subjects. ( Circ J 2010; 74: 2726-2733)
机译：背景：？细胞因子基因多态性与川崎病（KD）易感性之间的关系仍存在争议，因此本研究的目的是研究9种细胞因子基因（白介素（IL）-1A，IL）的14种多态性之间的关系。 -1B，IL-1RN，IL-4，IL-6，IL-8，IL-10，肿瘤坏死因子A和转化生长因子B）具有KD风险。方法和结果：总共招募了211名KD儿童和221名成人对照组。所有对照在性别和种族方面均与KD患者频率匹配。 PCR和TaqMan测定用于基因分型。在14种多态性的基因型或等位基因类型频率上，KD儿童与成人对照之间没有显着差异。在IL-1B，IL-4，IL-8和IL-10细胞因子基因构建的单倍型与KD风险之间未发现显着关联。此外，当这些单核苷酸多态性组合在一起时，观察到线性趋势，这由高风险基因型数量增加导致KD风险增加证明（P 线性趋势 = 0.002）。在年龄和性别分层分析中，随着年龄> 12个月（P = 0.014）或女性（P = 0.001）的高风险基因型数量的增加，KD风险呈线性趋势。结论：？未观察到个体细胞因子基因多态性与KD易感性之间的关联，但发现基因剂量对KD风险有影响，特别是对于年龄较大或女性的受试者。 （Circ J 2010; 74：2726-2733）

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