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首页> 外文期刊>Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine >Variability in Measures of Exhaled Breath Na+, Influence of Pulmonary Blood Flow and Salivary Na+
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Variability in Measures of Exhaled Breath Na+, Influence of Pulmonary Blood Flow and Salivary Na+

机译：呼气中Na +的测量值的变化，肺血流量和唾液Na +的影响

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The assessment of inflammatory markers and ions in exhaled breath condensate (EBC) is being utilized more frequently in diseases such as asthma and cystic fibrosis with marked variability in EBC measures, including those of exhaled Na+. We sought to determine if variability in exhaled Na+ was due to differences in pulmonary blood flow (PBF) or Na+ in the mouth (salivary Na+). We measured exhaled Na+ three times with coinciding sampling of salivary Na+ and assessment of PBF (using acetylene rebreathing) in 13 healthy subjects (54% female, age = 27 ± 7 yrs., ht. = 172 ± 10 cm, wt. = 70 ± 21 kg, BMI = 22 ± 7 kg/m2 mean ± SD). Exhaled Na+ averaged 2.7 ± 1.2 mmol/l, and salivary Na+ averaged 5.51 ± 4.58 mmol/l. The coefficients of variation across all three measures in all 13 subjects averaged 30% for exhaled Na+ and 83% for salivary Na+, within subjects the variability across the three measures averaged 30% for exhaled Na+ and 38% for salivary Na+. Across all three measures in all 13 subjects the relationship between PBF and exhaled Na+ averaged 0.027 (P = 0.87), and the relationship between salivary Na+ and exhaled Na+ concentrations averaged 0.59 (P = 0.001). Also, we sought to determine the relationship between exhaled Na+ and serum Na+ in an addition 20 subjects. There was a moderate and significant relationship between serum Na+ and exhaled Na+ (r = 0.37, P = 0.04). These findings suggest there that the variability in exhaled Na+ is caused, at least in part, by droplet formation from within the mouth as turbulent air passes through and that there is a flux of ions from the pulmonary blood into the airways.
机译：呼出气冷凝物（EBC）中炎症标志物和离子的评估在诸如哮喘和囊性纤维化等疾病中得到了更广泛的应用，这些疾病在EBC措施（包括呼出的Na +）中具有明显的可变性。我们试图确定呼出的Na +的变异性是否是由于肺血流量（PBF）或口腔中Na +（唾液Na +）的差异所致。我们对唾液中的Na +进行了三次采样，并对呼出的Na +进行了三次测量，并对13名健康受试者（54％的女性，年龄= 27±7岁，ht = 172±10 cm，体重= 70）的PBF（使用乙炔再呼吸）进行了评估±21公斤，BMI = 22±7公斤/平方米平均值±SD）。呼出的Na +平均为2.7±1.2 mmol / l，唾液中的Na +平均为5.51±4.58 mmol / l。在所有13个受试者中，所有三种测度的变异系数平均为呼出Na +的30％和唾液Na +的83％，在受试者中，呼气Na +的三种测度的变异性平均为30％和唾液Na +的38％。在所有13位受试者的所有三种测量中，PBF与呼出Na +之间的关系平均为0.027（P = 0.87），唾液Na +与呼出Na +浓度之间的关系平均为0.59（P = 0.001）。此外，我们试图确定另外20名受试者的呼出Na +与血清Na +之间的关系。血清Na +和呼出的Na +之间存在中度且显着的关系（r = 0.37，P = 0.04）。这些发现表明，呼出气中Na +的变化至少部分是由于湍流空气通过时口腔内液滴的形成以及离子从肺部血液进入呼吸道的通量而引起的。

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