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Efficacy and Safety of Remifentanil as an Alternative Labor Analgesic

机译：瑞芬太尼替代人工镇痛药的疗效和安全性

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摘要

The objective of this review was to evaluate the clinical efficacy and safety of remifentanil in the management of labor pain. Although neuraxial analgesia is the best option during labor, alternative analgesic options are needed for patients with contraindications. Using a systematic literature search, clinical outcomes of remifentanil for labor pain have been summarized. Also, comparisons of remifentanil to other options including meperidine, epidural analgesia, fentanyl, and nitrous oxide are provided. Based on the literature review, remifentanil is associated with high overall maternal satisfaction and favorable side-effect profile. However, due to the low reporting of adverse events, large, randomized controlled trials are needed to evaluate maternal and neonatal safety adequately and determine the optimal dosing needed to provide effective analgesia. While remifentanil is a feasible alternative for patients who cannot or do not want to receive epidural analgesia, administration should be monitored closely for potential adverse effects.
机译：这篇综述的目的是评估瑞芬太尼在治疗分娩痛中的临床疗效和安全性。尽管在分娩过程中神经镇痛是最好的选择，但禁忌症患者仍需要其他镇痛选择。通过系统的文献检索，已总结了瑞芬太尼治疗分娩痛的临床疗效。此外，还提供了瑞芬太尼与其他选择的比较，包括哌啶，硬膜外镇痛，芬太尼和一氧化二氮。根据文献综述，瑞芬太尼与较高的总体母亲满意度和良好的副作用有关。但是，由于不良事件的报道较少，需要进行大型，随机对照试验，以充分评估孕产妇和新生儿的安全性，并确定提供有效镇痛所需的最佳剂量。对于不能或不想接受硬膜外镇痛的患者，瑞芬太尼是一种可行的选择，但应密切监测给药的潜在不良反应。

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