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首页> 外文期刊>Clinical, Cosmetic and Investigational Dermatology >Combination of new multifunctional molecules for erythematotelangiectatic rosacea disorder
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Combination of new multifunctional molecules for erythematotelangiectatic rosacea disorder

机译：新型多功能分子联合治疗红斑性毛细血管扩张性酒渣鼻症

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Background: Rosacea, a common chronic skin disorder, is currently managed by patient education, pharmacological drugs, medical devices (laser and light therapies), and use of proper skin cares. Unfortunately, none of these actual treatments used alone or in combination is curative, and so we proposed a dermocosmetic active ingredient to mitigate some aspects of the rosacea and particularly for erythematotelangiectatic rosacea. Methods: Dermocosmetic active ingredient is composed of three glucosylated derivatives of natural plants hydroxybenzoic acid and hydroxycinnamic acids (rosmarinic acid, gallic acid, and caffeic acid). Anti-inflammatory, anti-angiogenesis, and anti-degranulation studies were done on cellular models (keratinocytes, mast cells, and endothelial cells). Efficiency of the active ingredient in comparison to placebo was assessed clinically on human volunteers having erythematotelangiectatic rosacea. The active and placebo were applied topically twice a day for 28 days. Biometrical analyses were done using a siascope tool. Results: We found that the active ingredient decreases inflammation (inhibition of interleukin-8 and tumor necrosis factor release), decreases degranulation of mast cells (inhibition of histamine release), and controls angiogenesis mechanism (inhibition of the production of vascular endothelial growth factor and neovessel formation) on cellular models. Study on human volunteers confirmed macroscopically the efficiency of this active ingredient, as we observed no neovessel formation and less visible vessels. Conclusion: Although rosacea is a skin condition disorder that is difficult to heal, the studies have shown that this active ingredient could be a dermocosmetic support, especially for erythematotelangiectatic rosacea armamentarium. The active ingredient was topically applied on the face for 28 days and improved erythematotelangiectatic rosacea symptoms either by decreasing them (vessels are less visible) or by limiting their development (any neovessels). The active ingredient decreases inflammation (inhibition of interleukin-8 and tumor necrosis factor release), decreases degranulation of mast cells (inhibition of histamine release), and limits the angiogenesis process (inhibition of vascular endothelial growth factor production and neovessel formation).
机译：背景：酒渣鼻是一种常见的慢性皮肤病，目前通过患者教育，药理药物，医疗设备（激光和光疗）以及适当的皮肤护理来治疗。不幸的是，这些单独或联合使用的实际治疗方法均不能治愈，因此我们提出了皮肤美容活性成分来减轻酒渣鼻的某些方面，特别是对于红斑毛细血管扩张性酒渣鼻。方法：皮肤美容活性成分由天然植物羟基苯甲酸和羟基肉桂酸（迷迭香酸，没食子酸和咖啡酸）的三种葡糖基化衍生物组成。在细胞模型（角质形成细胞，肥大细胞和内皮细胞）上进行了抗炎，抗血管生成和抗脱颗粒研究。在患有红斑毛细血管扩张性酒渣鼻的人类志愿者上，对活性成分与安慰剂的疗效进行了临床评估。活性剂和安慰剂每天局部使用两次，共28天。使用siascope工具进行生物特征分析。结果：我们发现该活性成分可减少炎症（抑制白介素8和肿瘤坏死因子的释放），减少肥大细胞的脱颗粒（抑制组胺的释放）并控制血管生成机制（抑制血管内皮生长因子和新血管形成）。对人类志愿者的研究从宏观上证实了这种活性成分的功效，因为我们没有观察到新血管的形成和可见血管的减少。结论：尽管酒渣鼻是一种皮肤病，很难治愈，但研究表明，该活性成分可以作为皮肤美容支持，特别是对于红斑毛细血管扩张型酒渣鼻。将该活性成分局部涂抹在脸上28天，并通过减少它们（不太明显的血管）或限制它们的发育（任何新血管）来改善红斑性毛细血管扩张性酒渣鼻症状。活性成分可减轻炎症（抑制白介素8和肿瘤坏死因子的释放），减少肥大细胞的脱粒（抑制组胺的释放），并限制血管生成过程（抑制血管内皮生长因子的产生和新血管的形成）。

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