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首页> 外文期刊>Clinical, Cosmetic and Investigational Dermatology >Spectrum of autoimmune vesiculobullous diseases in Iran: a 13-year retrospective study
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Spectrum of autoimmune vesiculobullous diseases in Iran: a 13-year retrospective study

机译：伊朗自身免疫性囊泡性疾病的频谱：一项为期13年的回顾性研究

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Background: Autoimmune bullous diseases (ABDs) represent a group of rare, acquired disorders characterized by overlapping features with involvement of the skin and mucous membranes, resistance to treatment, and potential lethality that comprise pemphigus, bullous pemphigoid (BP), epidermolysis bullosa, dermatitis herpetiformis, and linear immunoglobulin A bullous dermatosis. Aim: The main aim of this study was to identify the epidemiologic characteristics and clinical courses of these common diseases in Hamadan, Iran. Few surveys have been carried out to demonstrate the whole spectrum of ABDs in the literature. Notably, in Hamadan we are the first. Materials and methods: This 13-year retrospective study was designed to evaluate all of documented data obtained from hospitalized patients with ABDs at Farshchian Hospital from October 1999 to October 2012. We collected information on epidemiologic data, clinical aspects, histologic findings, and therapy prescribed. Data were analyzed using SPSS. Results: Of 168 patients, 78% had pemphigus. The age of patients at presentation ranged from 1 month to 115 years, with a mean of 47.5±19.93 years. Mucosal or skin involvement of ABDs was statistically significant ( P <0.001). The incidence of ABDs differed significantly based on anatomic location ( P =0.003). We documented three deaths. Conclusion: Compared to previous literature, our findings showed equal epidemiologic properties in Iran. Although pemphigus was the most common ABD followed by BP, it is expected that in line with the global trend, an increase in BP will be driven by population aging in Iran.
机译：背景：自身免疫性大疱性疾病（ABD）代表一组罕见的获得性疾病，其特征是皮肤和粘膜受累具有重叠的特征，对治疗的抵抗力以及潜在的致死性，包括天疱疮，大疱性天疱疮（BP），大疱性表皮松解，皮炎疱疹样和线性免疫球蛋白A大疱性皮肤病。目的：本研究的主要目的是确定伊朗哈马丹这些常见疾病的流行病学特征和临床病程。很少有调查显示文献中ABD的全部范围。值得注意的是，在哈马丹我们是第一位。资料和方法：这项为期13年的回顾性研究旨在评估从1999年10月至2012年10月在Farshchian医院住院的ABD患者获得的所有文献资料。 。使用SPSS分析数据。结果：在168例患者中，有78％患有天疱疮。就诊患者的年龄为1个月至115岁，平均为47.5±19.93岁。 ABD的粘膜或皮肤受累具有统计学意义（P <0.001）。根据解剖位置，ABD的发生率差异显着（P = 0.003）。我们记录了三人死亡。结论：与以前的文献相比，我们的发现显示伊朗具有相同的流行病学特征。尽管天疱疮是紧随其后的最常见的ABD，但预计随着全球趋势，伊朗人口老龄化将推动BP的增长。

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