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首页> 外文期刊>National Journal of Laboratory Medicine >A Two Year Retrospective Study of Direct Immunofluorescence in Autoimmune Vesiculobullous Lesions with Clinical Correlation
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A Two Year Retrospective Study of Direct Immunofluorescence in Autoimmune Vesiculobullous Lesions with Clinical Correlation

机译：自身免疫性血管性胆囊病变的直接免疫荧光两年回顾性研究与临床相关性

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Introduction: Autoimmune bullous lesions are diverse group of diseases characterised by blisters in the skin with or without mucosal lesions. They present with great degree of clinical and histopathological overlap; hence, advanced immunological methods like direct and indirect immunofluorescence techniques have become essential for accurate diagnosis in most of these cases. Aim: To study the pattern, intensity of immunofluorescence among various autoimmune vesiculobullous lesions with clinical correlation. Materials and Methods: This present study was a retrospective one in which 36 cases of vesiculobullous lesions were included. In Direct Immuno Fluorescence (DIF) the type of immunoglobulin expressed, pattern of deposition and its intensity was noted. Statistical method was used to calculate percentages, ratio, sensitivity and specificity. Results: The mean age in the study group was 46.2 years (SD±17.9) with male to female ratio 1.2:1. Most common lesion was pemphigus vulgaris in 12 (33.3%) cases. Most common site of the lesions were trunk 11 cases (30.5%), followed by upper extremity in 8 cases (22.2%). Only in 8 (22.2%) cases histopathological correlation was done. DIF was positive in 31 cases (86.1%). IgG was present in 25 (69.4%) patients, C3 was positive in 14 (38.8%) cases and IgM was present in 6 (16.6%) patients. DIF was inconclusive in 5 (13.8%) cases. Intensity of 3+ IgG was seen in 2 (16.6%) cases of pemphigus vulgaris followed by 2+ intensity in 5 (41.6 %) cases. C3 was positive in 14 (38.8%) cases with 2+ expression seen in 4 (30.4%) cases. Conclusion: DIF is a helpful diagnostic test in autoimmune vesiculobullous lesions even in absence of histopathological correlation.
机译：简介：自身免疫性大疱性病变是多种疾病，特征是皮肤有或没有粘膜病变的水泡。它们表现出很大程度的临床和组织病理学重叠。因此，在大多数情况下，像直接和间接免疫荧光技术这样的先进免疫学方法对于准确诊断已经变得至关重要。目的：研究各种自身免疫性囊泡性病变中免疫荧光的模式，强度，并与临床相关。材料和方法：本研究是一项回顾性研究，其中包括36例囊泡性病变。在直接免疫荧光（DIF）中，表达的免疫球蛋白类型，沉积模式及其强度均被记录下来。统计方法用于计算百分比，比率，敏感性和特异性。结果：研究组的平均年龄为46.2岁（SD±17.9），男女之比为1.2：1。最常见的病变是寻常型天疱疮，占12例（33.3％）。病变最常见的部位是躯干11例（30.5％），其次是上肢8例（22.2％）。仅在8例（22.2％）病例中进行了组织病理学相关性分析。 DIF阳性31例（86.1％）。 25例（69.4％）患者中存在IgG，14例（38.8％）患者中C3阳性，6例（16.6％）患者中存在IgM。 DIF在5例（13.8％）病例中没有定论。寻常天疱疮2例（16.6％）出现3+ IgG强度，随后5例（41.6％）出现2+强度。 C3阳性14例（38.8％），2+表达4例（30.4％）。结论：即使没有组织病理学相关性，DIF仍可对自身免疫性囊泡性病变进行诊断。

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