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Lowered intraocular pressure in a glaucoma patient after intravitreal injection of ocriplasmin

机译：玻璃体腔注射环孢菌素后青光眼患者的眼内压降低

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Abstract: We report the case of a glaucoma patient who received a single intravitreal injection of 125 μg ocriplasmin for vitreomacular traction in the right eye. The patient had bilateral advanced glaucoma and had previously undergone an implantation of an Ahmed glaucoma valve in the right eye and trabeculectomy in both eyes. The patient was using three topical ophthalmic intraocular pressure (IOP)-lowering medications on the day of injection. Baseline uncorrected Snellen visual acuity was 20/80-1 and IOP was 19 mmHg. Resolution of vitreomacular traction was achieved 1 week after injection. IOP was transiently decreased, reaching a maximum reduction of 12 mmHg below baseline at 1 month after injection, when serous choroidal effusion was also present. IOP returned to baseline levels and choroidal effusion resolved at 2 months after injection of IOP-lowering medication. Vitrectomy with epiretinal membrane and internal limiting membrane peeling, endolaser photocoagulation, and fluid–gas exchange were performed in the right eye ~3.5 months after injection to treat persistent epiretinal membrane, and presumed tractional retinal detachment. Final visual acuity was 20/50+ and IOP was 18 mmHg at 16 weeks after surgery. To our knowledge, this is the first report of IOP reduction and serous choroidal effusion after ocriplasmin injection.
机译：摘要：我们报道了一名青光眼患者的病例，该患者接受玻璃体腔内单次注射125μg环孢菌素用于右眼玻璃体牵引。该患者患有双侧晚期青光眼，并且先前曾在右眼植入Ahmed青光眼瓣膜并在两只眼睛中进行了小梁切除术。该患者在注射当天使用了三种降低局部眼内压（IOP）的药物。基线未矫正的Snellen视力为20 / 80-1，IOP为19 mmHg。注射后1周即可达到玻璃体牵引的分辨率。注射后1个月，当还存在浆液性脉络膜积液时，眼压会暂时降低，最大降低量低于基线12 mmHg。注射降眼压药物后2个月，眼压恢复至基线水平，脉络膜积液消失。注射后约3.5个月在右眼进行玻璃体切除术，该膜具有视网膜前膜和内部限制膜剥离，激光内凝剂光凝和液-气交换，以治疗顽固性视网膜前膜，并推测为视网膜牵引性脱离。术后16周的最终视力为20/50 +，IOP为18 mmHg。据我们所知，这是注射针cri素后眼压降低和浆液性脉络膜积液的首次报道。

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