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Alteration of Semantic Networks during Swear Words Processing in Schizophrenia

机译：精神分裂症发誓词处理过程中语义网络的变化

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Objective Positive symptoms, such as delusion and hallucination, commonly include negative emotional content in schizophrenia. We investigated the neural basis implicated during the processing of strong negative emotional words in patients with schizophrenia. Methods In our study, 35 patients with schizophrenia and 19 healthy controls were recruited, and the participants were asked to passively view the words that contained swearing and neutral content during functional magnetic resonance imaging. Results Patients with schizophrenia, compared to healthy controls, showed hypoactivation to the swear and neutral words stimuli in the left inferior frontal gyrus, left middle frontal gyrus, and left angular/supramarginal gyrus. More specifically, patients with remitted schizophrenia were found to have greater activation to the stimuli in the left middle/inferior frontal gyrus than patients with active schizophrenia. Furthermore, in the analysis of regions of interests, the left inferior and middle frontal gyrus activity was related to the severity of positive symptoms, including delusion and suspiciousness. Conclusion Our results suggest that patients with schizophrenia have difficulty in semantic processing and inhibitory control of swear words, and these abnormalities may be connected with the severity of positive symptoms.
机译：目的积极症状，如妄想和幻觉，通常包括精神分裂症患者的消极情绪。我们调查了精神分裂症患者强烈的负面情绪词处理过程中涉及的神经基础。方法在我们的研究中，招募了35例精神分裂症患者和19名健康对照者，并要求参与者在功能性磁共振成像过程中被动观看包含脏话和中性内容的单词。结果与健康对照组相比，精神分裂症患者的左下额额回，左中额额回和左角/上arg回的发誓和中性词刺激均低下。更具体地说，发现患有精神分裂症的患者比患有活动性精神分裂症的患者对左中/额额下回的刺激的激活更大。此外，在感兴趣区域的分析中，左下额中回活动与阳性症状的严重程度有关，包括妄想和可疑。结论我们的结果表明，精神分裂症患者在语义处理和抑制脏话方面存在困难，这些异常可能与阳性症状的严重程度有关。

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