One-pot, solvent-free synthesis via Biginelli reaction: Catalyst-free and new recyclable catalysts

Mahmood Kamali; Abbas Shockravi; Maryam Saghafi Doost; Seyyed Emad Hooshmand

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One-pot, solvent-free synthesis via Biginelli reaction: Catalyst-free and new recyclable catalysts

机译：通过Biginelli反应进行一锅无溶剂合成：无催化剂和新型可回收催化剂

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Free catalyst one-pot three components coupling of aldehydes, β-dicarbonyl compounds, and urea was performed to afford both the corresponding 3,4-dihydropyrimidine-2-ones (DHPOs, (1–9)a) and their sulfur analogs 3,4-dihydropyrimidine-2-thiones (DHPTs, (1–9)b), synthesized in the presence of uranyl acetate (UA) and succinimide sulfonic acid (SuSA) as catalysts under the same conditions via Biginelli condensation protocol. Interestingly, the free catalyst reactions were performed for 4?h for DHPOs with the yields of high to excellent, while in the cases of DHPTs, the yield was lower. But when the UA or SuSA was used, the yields (both of DHPOs and DHPTs) were high to excellent and the reaction times were either 2.5 or 1?h, respectively. Also, these two catalysts were recyclable for four consecutive runs.

机译：进行醛，β-二羰基化合物和尿素的游离催化剂一锅三组分偶联，得到相应的3,4-二氢嘧啶-2-酮（DHPO，（1-9）a）及其硫类似物3， 4-二氢嘧啶-2-硫酮（DHPT，（1–9）b）是在乙酸铀酰（UA）和琥珀酰亚胺磺酸（SuSA）存在下，在相同条件下通过Biginelli缩合方案合成的。有趣的是，对于DHPOs，游离催化剂反应进行了4？h，产率高到极好，而在DHPT的情况下，产率较低。但是当使用UA或SuSA时，产率（DHPO和DHPT两者）都很高到极好，反应时间分别为2.5或1？h。而且，这两种催化剂可循环使用四次。

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《Cogent Chemistry》 |2015年第1期|共6页
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Mahmood Kamali; Abbas Shockravi; Maryam Saghafi Doost; Seyyed Emad Hooshmand;
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机译：使用新型合成的可回收催化剂通过Biginelli和Hantzsch反应一锅无溶剂地合成1,4-二氢吡啶和3,4-二氢嘧啶-2-酮
2. Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions [J] . Mohamed Ould M’hamed, Abdulrahman G. Alshammari, O. M. Lemine Applied Sciences . 2016,第12期

机译：无催化剂和无溶剂球磨条件下Biginelli反应的绿色高产一锅法
3. Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions [J] . Mohamed Ould M’hamed, Abdulrahman G. Alshammari, O. M. Lemine Applied Sciences . 2016,第12期

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机译：通过Biginelli反应实现一锅无溶剂合成：不含催化剂和新型可回收催化剂

One-pot, solvent-free synthesis via Biginelli reaction: Catalyst-free and new recyclable catalysts

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