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首页> 外文期刊>Comparative and functional genomics >Accurate Localization of the Integration Sites of Two Genomic Islands at Single-Nucleotide Resolution in the Genome ofBacillus cereusATCC 10987
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Accurate Localization of the Integration Sites of Two Genomic Islands at Single-Nucleotide Resolution in the Genome ofBacillus cereusATCC 10987

机译：在蜡样芽孢杆菌基因组中以单核苷酸分辨率准确定位两个基因岛的整合位点ATCC 10987

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We have identified two genomic islands, that is, BCEGI-1 and BCEGI-2, in the genome ofBacillus cereusATCC 10987, based on comparative analysis withBacillus cereusATCC 14579. Furthermore, by using the cumulative GC profile and performing homology searches between the two genomes, the integration sites of the two genomic islands were determined at single-nucleotide resolution. BCEGI-1 is integrated between 159705 bp and 198000 bp, whereas BCEGI-2 is integrated between the end of ORF BCE4594 and the start of the intergenic sequence immediately following BCE4626, that is, from 4256803 bp to 4285534 bp. BCEGI-1 harbors two bacterial Tn7 transposons, which have two sets of genes encoding TnsA, B, C, and D. It is generally believed that unlike the TnsABC+E pathway, the TnsABC+D pathway would only promote vertical transmission to daughter cells. The evidence presented in this paper, however, suggests a role of the TnsABC+D pathway in the horizontal transfer of some genomic islands.
机译：根据蜡样芽孢杆菌ATCC 14579的比较分析，我们在蜡样芽孢杆菌ATCC 10987的基因组中鉴定出两个基因组岛，即BCEGI-1和BCEGI-2。此外，通过使用累积GC谱并在两个基因组之间进行同源性搜索，以单核苷酸分辨率确定了两个基因组岛的整合位点。 BCEGI-1被整合在159705 bp和198000 bp之间，而BCEGI-2被整合在ORF BCE4594的末端和紧接BCE4626之后的基因间序列的开始之间，即从4256803 bp到4285534 bp。 BCEGI-1带有两个细菌Tn7转座子，它们具有两套编码TnsA，B，C和D的基因。通常认为，与TnsABC + E途径不同，TnsABC + D途径只会促进向子细胞的垂直传播。但是，本文提供的证据表明，TnsABC + D途径在某些基因组岛的水平转移中具有一定作用。

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