Anatomic, Hematologic, and Biochemical Features of C57BL/6NCrl Mice Maintained on Chronic Oral Corticosterone

Cassano Amy E; White Julie R; Penraat Kelley A; Wilson Christopher D; Rasmussen Skye; Karatsoreos Ilia N

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Anatomic, Hematologic, and Biochemical Features of C57BL/6NCrl Mice Maintained on Chronic Oral Corticosterone

机译：慢性口服皮质酮维持C57BL / 6NCrl小鼠的解剖，血液和生化特征

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Metabolicsyndromeisaconditionthattypicallyincludescentralobesity,insulinresistance,glucoseintolerance,dyslipidemia,andhypertension.Disruptionofthehypothalamic#8211;pituitary#8211;adrenalaxis,aregulatorofcorticosteronesecretion,occursinsomecasesofmetabolicsyndromeandobesity,andCushinghypercortisolemiaisassociatedwithobesityandmetabolicdisorders.WethereforeassessedanatomicandclinicalpathologyinC57BL/6NCrlmicetoevaluatetheeffectsofchroniccorticosteroneinthedrinkingwateratdosesof25,50,and100#956;g/mLfor25d.Treatedmicedevelopedobesity,glucoseintolerance,electrolyteaberrations,anddyslipidemiathatweredose-dependentandmostsevereinthe100-mu;g/mLtreatmentgroup.Toevaluatereturntonormalfunction,additionalC57BL/6NCrlmicereceivedcorticosterone-freewaterfor2wkafterthe25-dtreatmentperiod.Accordingtoresultsofgrossexamination,miceappearedtorecoverwithindaysofexogenouscorticosteronewithdrawal;however,adrenalglandvacuolationandprotein,lipid,andelectrolyteabnormalitiespersisted.Together,thesefindingssupportchroniccorticosteroneexposurethroughthedrinkingwaterasapotentiallyuseful,noninvasivemethodtoinducesomefeaturesofmetabolicsyndrome.

机译：Metabolicsyndromeisaconditionthattypicallyincludescentralobesity，胰岛素抵抗，glucoseintolerance，血脂异常，andhypertension.Disruptionofthehypothalamic＃8211;垂体＃8211;肾上腺，aregulatorofcorticosteronesecretion，occursinsomecasesofmetabolicsyndromeandobesity，andCushinghypercortisolemiaisassociatedwithobesityandmetabolicdisorders.WethereforeassessedanatomicandclinicalpathologyinC57BL / 6NCrlmicetoevaluatetheeffectsofchroniccorticosteroneinthedrinkingwateratdosesof25,50，和100＃956;克/ mLfor25d.Treatedmicedevelopedobesity，glucoseintolerance，electrolyteaberrations，anddyslipidemiathatweredose-dependentandmostsevereinthe100-为评估恢复正常功能，在25天的治疗期后，每2周额外补充C57BL / 6NCrmicer接受无皮质酮的水治疗。根据大体检查的结果，小鼠似乎在日复一日恢复，但因外源性皮质激素的消退而逐渐消失，但是，随着时间的推移，雌性，雌性，雌性，雌性，雌性，雌性，雌性，雌性，雌性，雌性，雌性和雌激素的摄入量都下降了。慢性皮质类固醇通过饮用水接触可能是有用的，非侵入性的方法，可诱发代谢综合征的某些特征。

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《Comparative Medicine》 |2012年第5期|共页
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Cassano Amy E; White Julie R; Penraat Kelley A; Wilson Christopher D; Rasmussen Skye; Karatsoreos Ilia N;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Anatomic, Hematologic, and Biochemical Features of C57BL/6NCrl Mice Maintained on Chronic Oral Corticosterone [J] . Cassano Amy E., White Julie R., Penraat Kelley A., Comparative Medicine . 2012,第5期

机译：慢性口服皮质酮维持的C57BL / 6NCrl小鼠的解剖，血液和生化特征
2. Neuroendocrine stress reactivity of male C57BL/6N mice following chronic oral corticosterone exposure during adulthood or adolescence [J] . Ziasmin Shahanoor, Razia Sultana, Madelyn R. Baker, Psychoneuroendocrinology: An International Journal . 2017,第期

机译：慢性口服皮质酮暴露于成年或青春期后雄性C57BL / 6N小鼠的神经内分泌应激反应性
3. Effect of chronic corticosterone application on depression-like behavior in C57BL/6N and C57BL/6J mice [J] . Sturm M., Becker A., Schroeder A., Genes, brain, and behavior . 2015,第3期

机译：长期应用皮质酮对C57BL / 6N和C57BL / 6J小鼠的抑郁样行为的影响
4. Effect of chronic RF-EMF exposure on aging-induced oxidative stress and neuroinflammation in C57BL/6 mice [C] . Ye Ji Jeong, Hyung-Do Choi, Jeong-Ki Pack, Joint Meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association . 2018

机译：慢性RF-EMF暴露对C57BL / 6小鼠衰老氧化应激和神经炎症的影响
5. An examination of the effects of chronic caffeine and withdrawal from chronic caffeine on fear conditioning in pre-adolescent, adolescent, and adult C57BL/6J mice. [D] . Poole, Rachel Lucile Flagg. 2014

机译：检查慢性咖啡因和退出慢性咖啡因对青春期前，青春期和成年C57BL / 6J小鼠的恐惧状况的影响。
6. Anatomic Hematologic and Biochemical Features of C57BL/6NCrl Mice Maintained on Chronic Oral Corticosterone [O] . Amy E Cassano, Julie R White, Kelley A Penraat, 2012

机译：慢性口服皮质酮维持的C57BL / 6NCrl小鼠的解剖血液和生化特征
7. Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse [O] . 2014

机译：长期暴露于皮质酮会降低C57BL / 6NCrl小鼠的胰岛素敏感性并引起抑郁样行为
8. 90-Day Oral Toxicity Study on n-Nonane in female Fisher 344 Rats and Male C57BL/6 Mice [R] . Dodd, D. R. , Wolfe, R. E. , Pollard, D. L. , 2003

机译：雌性Fisher 344大鼠和雄性C57BL / 6小鼠的正壬烷90天口服毒性研究

Anatomic, Hematologic, and Biochemical Features of C57BL/6NCrl Mice Maintained on Chronic Oral Corticosterone

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