• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative Medicine >Anatomic, Hematologic, and Biochemical Features of C57BL/6NCrl Mice Maintained on Chronic Oral Corticosterone
【24h】

Anatomic, Hematologic, and Biochemical Features of C57BL/6NCrl Mice Maintained on Chronic Oral Corticosterone

机译：慢性口服皮质酮维持的C57BL / 6NCrl小鼠的解剖，血液和生化特征

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Metabolic syndrome is a condition that typically includes central obesity, insulin resistance, glucose intolerance, dyslipidemia, and hypertension. Disruption of the hypothalamic-pituitary-adrenal axis, a regulator of corticosterone secretion, occurs in some cases of metabolic syndrome and obesity, and Cushing hypercortisolemia is associated with obesity and metabolic disorders. We therefore assessed anatomic and clinical pathology in C57BL/6NCrl mice to evaluate the effects of chronic corticosterone in the drinking water at doses of 25, 50, and 100 μg/mL for 25 d. Treated mice developed obesity, glucose intolerance, electrolyte aberrations, and dyslipidemia that were dose-dependent and most severe in the 100-mu;g/mL treatment group. To evaluate return to normal function, additional C57BL/6NCrl mice received corticosterone-free water for 2 wk after the 25-d treatment period. According to results of gross examination, mice appeared to recover within days of exogenous corticosterone withdrawal; however, adrenal gland vacuolation and protein, lipid, and electrolyte abnormalities persisted. Together, these findings support chronic corticosterone exposure through the drinking water as a potentially useful, noninvasive method to induce some features of metabolic syndrome.
机译：代谢综合征是通常包括中枢性肥胖，胰岛素抵抗，葡萄糖耐受不良，血脂异常和高血压的疾病。下丘脑-垂体-肾上腺轴（皮质酮分泌的调节剂）的破坏在某些代谢综合征和肥胖症中发生，库欣高皮质醇血症与肥胖症和代谢紊乱有关。因此，我们评估了C57BL / 6NCrl小鼠的解剖学和临床病理学，以评估25，50和100μg/ mL剂量的25 d饮用水中慢性皮质酮的作用。经治疗的小鼠出现肥胖，葡萄糖耐受不良，电解质畸变和血脂异常，这是剂量依赖性的，在100μg/ mL治疗组中最严重。为了评估恢复正常功能，在25天治疗期后的2周内，另外的C57BL / 6NCrl小鼠接受了无皮质酮的水治疗。根据粗略检查的结果，小鼠在外源皮质酮戒断后几天内似乎恢复了体力。然而，肾上腺空泡化以及蛋白质，脂质和电解质异常持续存在。总之，这些发现支持通过饮用水长期暴露于皮质酮是一种潜在的有用的，非侵入性的方法，可引起代谢综合征的某些特征。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号