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首页> 外文期刊>Colloids and Interfaces >Nanoparticle-Lipid Interaction: Job Scattering Plots to Differentiate Vesicle Aggregation from Supported Lipid Bilayer Formation
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Nanoparticle-Lipid Interaction: Job Scattering Plots to Differentiate Vesicle Aggregation from Supported Lipid Bilayer Formation

机译：纳米颗粒-脂类相互作用：作业散射图，以区分囊泡聚集与支持的脂质双层形成。

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摘要

The impact of nanomaterials on lung fluids, or on the plasma membrane of living cells, has prompted researchers to examine the interactions between nanoparticles and lipid vesicles. Recent studies have shown that nanoparticle-lipid interaction leads to a broad range of structures including supported lipid bilayers (SLB), particles adsorbed at the surface or internalized inside vesicles, and mixed aggregates. Currently, there is a need to have simple protocols that can readily evaluate the structures made from particles and vesicles. Here we apply the method of continuous variation for measuring Job scattering plots and provide analytical expressions for the scattering intensity in various scenarios. The result that emerges from the comparison between experiments and modeling is that electrostatics play a key role in the association, but it is not sufficient to induce the formation of supported lipid bilayers.
机译：纳米材料对肺液或活细胞质膜的影响促使研究人员研究纳米颗粒与脂质囊泡之间的相互作用。最近的研究表明，纳米颗粒与脂质的相互作用导致了广泛的结构，包括支持的脂质双层（SLB），吸附在表面或内在囊泡中的颗粒以及混合的聚集体。当前，需要具有可以容易地评估由颗粒和囊泡制成的结构的简单方案。在这里，我们应用连续变化的方法来测量Job散射图，并提供各种情况下散射强度的解析表达式。从实验和建模之间的比较得出的结果是，静电在缔合中起关键作用，但不足以诱导形成支持的脂质双层。

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