Differential Susceptibility of SD and CD Rats to a Novel Rat Theilovirus

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Differential Susceptibility of SD and CD Rats to a Novel Rat Theilovirus

机译：SD和CD大鼠对新型大鼠脊髓病毒的易感性

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Antibodiestorattheilovirus(RTV)havebeendetectedinratsformanyyearsbecauseoftheirserologiccrossreactivitywithstrainsofTheilermurineencephalomyelitisvirus(TMEV)ofmice.Littleinformationexistsregardingthispathogen,yetitisamongthemostcommonvirusesdetectedinserologicsurveysofratsusedinresearch.Inthestudyreportedhere,anovelisolateofRTV,designatedRTV1,wasculturedfromthefecesofinfectedrats.TheRTV1genomecontained8094nucleotidesandhadapproximately95%identitywithanotherrattheilovirus,NSG910,and73%identitywithTMEVstrains.Inaddition,thegenomesizeofRTV1wassimilartothoseofTMEVstrainsbutlargerthanthatreportedforNSG910.OralinoculationofSprague#8211;Dawley(SD)andCDmalerats(n=10eachgroup)withRTV1revealedthatSDratsweremoresusceptiblethanCDratstoRTV1infection.At14dpostinoculation,100%ofSDratsshedvirusinthefeces,and70%werepositiveforRTVserumantibodies.By56dpostinoculation30%ofSDratscontinuedtohavedetectablevirusinthefeces,and90%hadseroconverted.Incontrast,ininoculatedCDratsRTVwasdetectedonlyinthefecesat14dpostinoculation,atwhichtime40%ofCDratswerefecalpositive.By56dpostinoculationonly20%ofCDratshaddetectableRTVserumantibodies.Ourdataprovideadditionalsequenceinformationregardingarat-specificCardiovirusandindicatethatSDratsaremoresusceptiblethanCDratstoRTV1infection.

机译：Antibodiestorattheilovirus（RTV）havebeendetectedinratsformanyyearsbecauseoftheirserologiccrossreactivitywithstrainsofTheilermurineencephalomyelitisvirus（TMEV）ofmice.Littleinformationexistsregardingthispathogen，yetitisamongthemostcommonvirusesdetectedinserologicsurveysofratsusedinresearch.Inthestudyreportedhere，anovelisolateofRTV，designatedRTV1，wasculturedfromthefecesofinfectedrats.TheRTV1genomecontained8094nucleotidesandhadapproximately95％identitywithanotherrattheilovirus，NSG910，and73％identitywithTMEVstrains.Inaddition，thegenomesizeofRTV1wassimilartothoseofTMEVstrainsbutlargerthanthatreportedforNSG910.OralinoculationofSprague＃8211;雄性SD andCDmalerats（N = 10eachgroup）带有RTV1的标本表明，SD的标本比RTV1感染的CD标本的敏感性更高。在接种后14天，粪便中100％的SD标本中有散落的病毒，而RTV血清抗体的阳性率为70％。在这种情况下，在这种情况下，继续检测到可检出的CD上的可检出的病毒在10％的情况下一直被检测到，在这种情况下，可检测到的CD连续转染了SD鼠的比例为90％。进行小剂量接种时，此时40％的CD大鼠为阳性。到了56 d接种后，只有20％的CD大鼠具有可检测的RTV血清抗体。我们的数据提供了关于arat特异性心脏病毒的其他序列信息，并表明SD大鼠比CDV对RTV1感染的敏感性更高。

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《Comparative Medicine》 |2008年第5期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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Differential Susceptibility of SD and CD Rats to a Novel Rat Theilovirus

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