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首页> 外文期刊>Comparative Medicine >Differential susceptibility of SD and CD rats to a novel rat theilovirus
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Differential susceptibility of SD and CD rats to a novel rat theilovirus

机译：SD和CD大鼠对新型大鼠细小病毒的敏感性

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Antibodies to rat theilovirus (RTV) have been detected in rats for many years because of their serologic crossreactivity with strains of Theiler murine encephalomyelitis virus (TMEV) of mice. Little information exists regarding this pathogen, yet it is among the most common viruses detected in serologic surveys of rats used in research. In the study reported here, a novel isolate of RTV, designated RTV1, was cultured from the feces of infected rats. The RTV1 genome contained 8094 nucleotides and had approximately 95% identity with another rat theilovirus, NSG910, and 73% identity with TMEV strains. In addition, the genome size of RTV1 was similar to those of TMEV strains but larger than that reported for NSG910. Oral inoculation of Sprague-Dawley (SD) and CD male rats (n = 10 each group) with RTV1 revealed that SD rats were more susceptible than CD rats to RTV1 infection. At 14 d postinoculation, 100% of SD rats shed virus in the feces, and 70% were positive for RTV serum antibodies. By 56 d postinoculation 30% of SD rats continued to have detectable virus in the feces, and 90% had seroconverted. In contrast, in inoculated CD rats RTV was detected only in the feces at 14 d postinoculation, at which time 40% of CD rats were fecal positive. By 56 d postinoculation only 20% of CD rats had detectable RTV serum antibodies. Our data provide additional sequence information regarding a rat-specific Cardiovirus and indicate that SD rats are more susceptible than CD rats to RTV1 infection.
机译：在大鼠中已检测到鼠脊髓病毒（RTV）抗体多年，因为它们与小鼠泰勒鼠脑脊髓炎病毒（TMEV）株具有血清学交叉反应性。关于这种病原体的信息很少，但是它是在用于研究的大鼠的血清学调查中发现的最常见的病毒之一。在这里报道的研究中，从被感染大鼠的粪便中培养了一种新的RTV分离株，命名为RTV1。 RTV1基因组包含8094个核苷酸，与另一种大鼠脊髓病毒NSG910的同源性约为95％，与TMEV株的同源性为73％。此外，RTV1的基因组大小与TMEV菌株相似，但比NSG910报道的大。口服RTV1接种Sprague-Dawley（SD）和CD雄性大鼠（每组n = 10）显示，SD大鼠比CD大鼠更易感染RTV1。接种后第14天，SD大鼠100％排泄了粪便中的病毒，而RTV血清抗体阳性70％。到接种后第56天，有30％的SD大鼠的粪便中仍可检测到病毒，而90％的患者血清已转化。相反，在接种的CD大鼠中，仅在接种后14 d的粪便中检测到RTV，此时40％的CD大鼠为粪便阳性。接种后第56天，只有20％的CD大鼠具有可检测的RTV血清抗体。我们的数据提供了有关大鼠特异性心脏病毒的其他序列信息，并表明SD大鼠比CD大鼠更容易受到RTV1感染。

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