Histopathologic Findings and Establishment of Novel Tumor Lines from Spontaneous Tumors in FVB/N Mice

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Histopathologic Findings and Establishment of Novel Tumor Lines from Spontaneous Tumors in FVB/N Mice

机译：FVB / N小鼠自发性肿瘤的组织病理学发现和新型肿瘤细胞系的建立

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TheinbredFVBmousestrainisusedextensivelyincancerresearch.TransgenicmicewithanFVB/Nbackgroundinwhichtheexpressionofgreenfluorescentproteinisunderthecontrolofvariouspromotershavebeenusedwidelyforthelastdecade.However,littleisknownabouttheincidenceandcharacteristicsofspontaneoustumorsinthesemice.Inaddition,onlyafewtumorlineshavebeenestablishedforuseinthisparticularmousestrain.OuraimwastoinitiateadatabaseofspontaneoustumorsinourretiredFVB/Nbreeders,analyzethehistopathologiccharacteristicsofthesetumors,andestablishnoveltumorlinesinvivoandinvitro.Atotalof234(40male,194female)breedermicewereobservedduringtheirnaturallifespans.Theincidenceofspontaneoustumorswas45.0%inmalemiceand52.8%infemalemice.Alltumorsinmalemicewerelungalveolar#8211;bronchiolar(AB)neoplasms,exceptfor1testisinterstitialcelltumor.Infemalemice,histopathologicexaminationrevealed48lungABtumors,27mammaryglandtumors,13ovariantumors,and14othertumors.SeveralofthesespontaneoustumorshavebeentransplantedintoFVB/Nmice.Onemammaryadenocarcinoma(MCaP0008)and1lungABcarcinoma(LAP0297)weresuccessfullytransplantedsubcutaneouslyandpassagedseriallyinvivo.Subsequently,weestablishedcelllinesfrombothtumors,whichweremaintainedinmonolayerinvitro.BothofthegraftedtumorsandcelllinesaretumorigenicinVEGFsupP/sup-GFP/FVBandTie2supP/sup-GFP/FVBmice.Establishmentofthesenoveltumorlineswillbenefitbothinvivoandinvitrostudiesonthepathophysiologyofcancerinthisrelativelynewbutwidelyusedmousestrain.

机译：TheinbredFVBmousestrainisusedextensivelyincancerresearch.TransgenicmicewithanFVB / Nbackgroundinwhichtheexpressionofgreenfluorescentproteinisunderthecontrolofvariouspromotershavebeenusedwidelyforthelastdecade.However，littleisknownabouttheincidenceandcharacteristicsofspontaneoustumorsinthesemice.Inaddition，onlyafewtumorlineshavebeenestablishedforuseinthisparticularmousestrain.OuraimwastoinitiateadatabaseofspontaneoustumorsinourretiredFVB / Nbreeders，analyzethehistopathologiccharacteristicsofthesetumors，andestablishnoveltumorlinesinvivoandinvitro.Atotalof234（40male，194female）breedermicewereobservedduringtheirnaturallifespans.Theincidenceofspontaneoustumorswas45.0％inmalemiceand52.8％infemalemice.Alltumorsinmalemicewerelungalveolar＃8211;支气管（AB）肿瘤，除1个睾丸间质细胞瘤外。对女性小鼠，组织病理学检查显示了48个肺部AB肿瘤，27个乳腺肿瘤，13个卵巢肿瘤和14个其他肿瘤。其中一些自发性肿瘤已被移植到FVB / Nice中。 cinoma（MCaP0008）and1lungABcarcinoma（LAP0297）weresuccessfullytransplantedsubcutaneouslyandpassagedseriallyinvivo.Subsequently，weestablishedcelllinesfrombothtumors，whichweremaintainedinmonolayerinvitro.BothofthegraftedtumorsandcelllinesaretumorigenicinVEGF ^{P -GFP / FVBandTie2 ^{P -GFP / FVBmice.Establishmentofthesenoveltumorlineswillbenefitbothinvivoandinvitrostudiesonthepathophysiologyofcancerinthisrelativelynewbutwidelyusedmousestrain。}}

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《Comparative Medicine》 |2008年第3期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Histopathologic Findings and Establishment of Novel Tumor Lines from Spontaneous Tumors in FVB/N Mice. [J] . Huang P., Duda D.G., Jain R.K., Comparative Medicine . 2008,第3期

机译：FVB / N小鼠自发性肿瘤的组织病理学发现和新型肿瘤细胞系的建立。
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6. Histopathologic Findings and Establishment of Novel Tumor Lines from Spontaneous Tumors in FVB/N Mice [O] . Peigen Huang, Dan G Duda, Rakesh K Jain, 2008

机译：FVB / N小鼠自发性肿瘤的组织病理学发现和新型肿瘤细胞系的建立
7. Establishment of Highly Tumorigenic Human Gastric Carcinoma Cell Lines from Xenograft Tumors in Mice [O] . Kyung-A Song, Jihyun Park, Ha-Jung Kim, 2017

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Histopathologic Findings and Establishment of Novel Tumor Lines from Spontaneous Tumors in FVB/N Mice

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