Renal Function and Hematology in Rats with Congenital Renal Hypoplasia

Yasuda Hidenori; Amakasu Kohei; Tochigi Yuki; Katayama Kentaro; Suzuki Hiroetsu

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Renal Function and Hematology in Rats with Congenital Renal Hypoplasia

机译：先天性肾发育不全大鼠的肾功能和血液学

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Renalhypoplasiaduetoacongenitallyreducednumberofnephronsprogressestochronickidneydiseaseandmaycauserenalanemia,giventhatthekidneysareamajorsourceoferythropoietininadults.Hypoplastickidney(HPK)ratshaveonlyabout20%ofthenormalnumberofnephronsanddevelopCKD.ThisstudyassessedtherenalfunctionandhematologicchangesinHPKratsfrom70to210dofage.HPKratsdemonstrateddeteriorationofrenalexcretoryfunction,slightlymacrocyticerythropeniaatalldaysexamined,age-relatedincreasesinsplenichemosiderosisaccompaniedbyatendencytowardincreasedhemolysis,normalplasmaerythropoietinlevelsassociatedwithincreasedhepaticanddecreasedrenalerythropoietinproduction,andmaintenanceoftheresponseforerythropoietinproductiontohypoxicconditions,withincreasedinterstitialfibrosisat140dofage.TheseresultsindicatethatincreasesinsplenichemosiderosisandthemembranefragilityofRBCmightbeassociatedwitherythropeniaandthathepaticproductionoferythropoietinmightcontributetomaintainingthebloodHgbconcentrationinHPKrats.

机译：Renalhypoplasiaduetoacongenitallyreducednumberofnephronsprogressestochronickidneydiseaseandmaycauserenalanemia，giventhatthekidneysareamajorsourceoferythropoietininadults.Hypoplastickidney（HPK）ratshaveonlyabout20％ofthenormalnumberofnephronsanddevelopCKD.ThisstudyassessedtherenalfunctionandhematologicchangesinHPKratsfrom70to210dofage.HPKratsdemonstrateddeteriorationofrenalexcretoryfunction，slightlymacrocyticerythropeniaatalldaysexamined，年龄relatedincreasesinsplenichemosiderosisaccompaniedbyatendencytowardincreasedhemolysis，normalplasmaerythropoietinlevelsassociatedwithincreasedhepaticanddecreasedrenalerythropoietinproduction，andmaintenanceoftheresponseforerythropoietinproductiontohypoxicconditions，withincreasedinterstitialfibrosisat140dofage.TheseresultsindicatethatincreasesinsplenichemosiderosisandthemembranefragilityofRBCmightbeassociatedwitherythropeniaandthathepaticproductionoferythropoietinmightcontributetomaintainingthebloodHgbconcentrationinHPKrats。

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《Comparative Medicine》 |2016年第1期|共页
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Yasuda Hidenori; Amakasu Kohei; Tochigi Yuki; Katayama Kentaro; Suzuki Hiroetsu;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Renal Function and Hematology in Rats with Congenital Renal Hypoplasia [J] . Yasuda Hidenori, Amakasu Kohei, Tochigi Yuki, Comparative Medicine . 2016,第1期

机译：先天性肾发育不全大鼠的肾功能和血液学
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6. A novel heterozygous GLI2 mutation in a patient with congenital urethral stricture and renal hypoplasia/dysplasia leading to end-stage renal failure [O] . Toshihiko Shirakawa, Yumiko Nakashima, Satoshi Watanabe, 2018

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Renal Function and Hematology in Rats with Congenital Renal Hypoplasia

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