Spontaneous Osteoarthritis in Dunkin Hartley Guinea Pigs: Histologic, Radiologic, and Biochemical Changes

Jimenez Pablo A.; Glasson Sonya S.; Trubetskoy Olga V.; Haimes Howard B.

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Spontaneous Osteoarthritis in Dunkin Hartley Guinea Pigs: Histologic, Radiologic, and Biochemical Changes

机译：Dunkin Hartley豚鼠的自发性骨关节炎：组织学，放射学和生化变化

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DunkinHartleyguineapigsdevelopspontaneous,age-relatedosteoarthritis(OA)ofthekneeandotherjoints.Histologicchangesareobservedbeginningat3monthsofage.Diseaseseverityincreaseswithage,andat18monthsmoderatetosevereOAisobserved.Astudywasundertakentoassessthemorphologicandbiochemicalchangesof22-month-oldanimals,andtocomparethemwithvaluesin2-month-oldguineapigs.BiochemicalindicescharacteristicofOA,fromtibialcartilage,indicatedanincreaseinproteoglycancontentfrom233±2#59157;g/mg(mean±SEM)at2monthsofageto365±6#59157;g/mgat22months.Collagenconcentrationincartilagedecreasedfrom364±2#59157;g/mgat2monthsto223±3#59157;g/mgat22months.Proteoglycanfragmentsfoundinsynovialfluidmeasured4.6±1g/mlat2monthsandincreasedto37±2#59157;g/mlat22months.Radiographicchangesobservedat22monthsincludedmarginalosteophytesofthetibiaandfemur,sclerosisofthesubchondralboneofthetibialplateau,femoralcondylecysts,andcalcificationofthecollateralligaments.HistologicevaluationrevealedsevereOA,withaMankinscoreof10.7±0.5in22-month-oldanimals.Incontrast,2-month-oldanimalshadnohistologicorradiographicallydetectablelesions.TheresultsofthestudyreportedhereindicatethatthelesionsobservedinthismodelaresimilartothoseofhumanOA.SpontaneousdevelopmentofOAinguineapigsisamenabletothestudyofthepathogenesisofOAandtotheevaluationofpotentialdisease-modifyingagents.

机译：DunkinHartleyguineapigsdevelopspontaneous，年龄relatedosteoarthritis（OA）ofthekneeandotherjoints.Histologicchangesareobservedbeginningat3monthsofage.Diseaseseverityincreaseswithage，andat18monthsmoderatetosevereOAisobserved.Astudywasundertakentoassessthemorphologicandbiochemicalchangesof22个月oldanimals，andtocomparethemwithvaluesin2个月oldguineapigs.BiochemicalindicescharacteristicofOA，fromtibialcartilage，indicatedanincreaseinproteoglycancontentfrom233±2＃59157克/毫克（平均值±SEM）at2monthsofageto365±6＃ 59157克/ mgat22months.Collagenconcentrationincartilagedecreasedfrom364±2＃59157克/ mgat2monthsto223±3＃59157克/ mgat22months.Proteoglycanfragmentsfoundinsynovialfluidmeasured4.6±1G / mlat2monthsandincreasedto37±2＃59157克/ mlat22months.Radiographicchangesobservedat22monthsincludedmarginalosteophytesofthetibiaandfemur，sclerosisofthesubchondralboneofthetibialplateau，femoralcondylecysts，andcalcificationofthecollateralligaments.HistologicevaluationrevealedsevereOA， 22个月大时的Mankins评分为10.7±0.5相比之下，两个月大的动物阴影没有组织学或放射学上可检测的病变。报告的软性研究表明，该病变与人类OA的模型相似。自发地发展OA的apiapisisa值得研究，并研究潜在的病原体。

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《Comparative Medicine》 |1997年第6期|共页
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Jimenez Pablo A.; Glasson Sonya S.; Trubetskoy Olga V.; Haimes Howard B.;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes. [J] . Jimenez PA, Glasson SS, Trubetskoy OV, Laboratory Animal Science . 1997,第6期

机译：Dunkin Hartley豚鼠的自发性骨关节炎：组织学，放射学和生化变化。
2. SPONTANEOUS OSTEOARTHRITIS IN HARTLEY,DUNKIN GUINEA PIGS - HISTOLOGIC, RADIOLOGIC, AND BIOCHEMICAL CHANGES [J] . Jimenez PA, Glasson SS, Trubetskoy OV, Laboratory Animal Science . 1997,第6期

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4. EFFECT OF SHARK SKIN COLLAGEN ON MORPHOLOGIC AND BIOCHEMICAL CHANGES IN A GUINEA PIG MODEL OF OSTEOARTHRITIS [C] . T. ATSUGI, Y. NOMURA, M. WATANABE Annual Meeting of the Japanese Association for Animal Cell Technology . 2003

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5. Determining the role of interleukin-1beta in the Hartley guinea pig model of primary osteoarthritis. [D] . Santangelo, Kelly Susan. 2011

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6. The Dunkin Hartley Guinea Pig Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human Musculoskeletal Aging [O] . Robert V. Musci, Maureen A. Walsh, Adam R. Konopka, 2020

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7. Study of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs. [O] . Legrand, Catherine, Centonze, Prescilia, Comblain, Fanny, 2017

机译：在Dunkin-Hartley豚鼠的自发性骨关节炎模型中研究骨关节炎病理变化和软骨的力学特性。

Spontaneous Osteoarthritis in Dunkin Hartley Guinea Pigs: Histologic, Radiologic, and Biochemical Changes

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