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首页> 外文期刊>Laboratory Animal Science >Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes.
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Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes.

机译：Dunkin Hartley豚鼠的自发性骨关节炎：组织学，放射学和生化变化。

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Dunkin Hartley guineapigs develop spontaneous, age-related osteoarthritis. A study was undertaken to assess the morphological and biochemical changes in fourteen 22-month-old Dunkin Hartley guineapigs, and to compare them with values in eight 2-month-old guineapigs. Biochemical indices characteristic of OA, from tibial cartilage, indicated an increase in proteoglycan content from 233? 鎔/mg (mean駍.e.m.) at 2 months of age to 365? 鎔/mg at 22 months. Collagen concentration in cartilage decreasedfrom 364? 鎔/mg at 2 months to 223? 鎔/mg at 22 months. Proteoglycan fragments found in synovial fluid measured 4.6? 鎔/mg at 2 months and increased to 37? 鎔/ml at 22 months. Radiographic changes observed at 22 months included marginal osteophytes of the tibia and femur, sclerosis of the subchondral bone of the tibial plateau, femoral condyle cysts and calcification of the collateral ligaments. Histological evaluation revealed severe OA, with a Mankin score of 10.7?.5 in 22-month-old animals. In contrast, 2-month-old animals had no histological or radiographically detectable lesions. It is suggested that the lesions observed in this model are similar to those of human OA and that spontaneous development of OA in guineapigs is amenable to the study of the pathogenesis of OA and to the evaluation of potential disease-modifying agents.
机译：邓金·哈特利（Dunkin Hartley）的几内亚胺会自发发生与年龄相关的骨关节炎。进行了一项研究，以评估14个22个月大的Dunkin Hartley几内亚猪的形态和生化变化，并将其与8个2个月大的几内亚猪的值进行比较。来自胫骨软骨的骨关节炎的生化指标表明，蛋白聚糖的含量从233？增加了。 2 / mg（mean駍.e.m。）在2个月大时至365？ months / mg在22个月时。软骨中的胶原蛋白浓度从364？ 2个月时的镕/ mg至223？ months / mg在22个月时。滑液中发现的蛋白聚糖片段为4.6？ months / mg在2个月时增加到37？ months / ml在22个月时。在22个月时观察到的影像学变化包括胫骨和股骨的边缘骨赘，胫骨平台的软骨下骨的硬化，股骨dy囊肿和副韧带的钙化。组织学评估显示，在22个月大的动物中，OA严重，Mankin评分为10.7？.5。相反，两个月大的动物没有组织学或放射学上可检测的病变。提示在该模型中观察到的病变与人OA相似，并且几内亚皮中OA的自发发展适合于OA的发病机理研究和潜在的疾病改良剂的评估。

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