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首页> 外文期刊>Laboratory Animal Science >SPONTANEOUS OSTEOARTHRITIS IN HARTLEY,DUNKIN GUINEA PIGS - HISTOLOGIC, RADIOLOGIC, AND BIOCHEMICAL CHANGES
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SPONTANEOUS OSTEOARTHRITIS IN HARTLEY,DUNKIN GUINEA PIGS - HISTOLOGIC, RADIOLOGIC, AND BIOCHEMICAL CHANGES

机译：哈特利，邓肯几内亚猪的自发性骨关节炎-组织学，放射学和生物化学变化

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Dunkin Hartley guinea pigs develop spontaneous, age-related osteoarthritis (OA) of the knee and other joints, Histologic changes are observed beginning at 3 months of age, Disease severity increases with age, and at 18 months moderate to severe OA is observed. A study was undertaken to assess the morphologic and biochemical changes of 22-month-old animals, and to compare them with values in a-month-old guinea pigs. Biochemical indices characteristic of OA, from tibial cartilage, indicated an increase in proteoglycan content from 233 +/- 2 mu g/mg (mean +/- SEM) at 2 months of age to 365 +/- 6 mu g/mg at 22 months. Collagen concentration in cartilage decreased from 364 +/- 2 mu g/mg at 2 months to 223 +/- 3 mu g/mg at 22 months. Proteoglycan fragments found in synovial fluid measured 4.6 +/- 1 mu g/ml at 2 months and increased to 37 +/- 2 mu g/ml at 22 months. Radiographic changes observed at 22 months included marginal osteophytes of the tibia and femur, sclerosis of the subchondral bone of the tibial plateau, femoral condyle cysts, and calcification of the collateral ligaments, Histologic evaluation revealed severe OA, with a Mankin score of 10.7 +/- 0.5 in 22-month-old animals. In contrast, 2-month-old animals had no histologic or radiographically detectable lesions. The results of the study reported here indicate that the lesions observed in this model are similar to those of human OA. Spontaneous development of OA in guinea pigs is amenable to the study of the pathogenesis of OA and to the evaluation of potential disease-modifying agents.
机译：邓金·哈特利（Dunkin Hartley）豚鼠自发出现与年龄有关的膝盖和其他关节骨关节炎（OA），从3个月大开始观察组织学变化，疾病严重程度随年龄增长而增加，在18个月时观察到中度至重度OA。进行了一项研究，以评估22个月大动物的形态和生化变化，并将其与一个月大的豚鼠的值进行比较。胫骨软骨的OA特征性生化指标表明蛋白聚糖含量从2个月大时的233 +/- 2μg / mg（平均+/- SEM）增加到22个月时的365 +/- 6μg / mg个月。软骨中的胶原蛋白浓度从2个月时的364 +/- 2μg / mg降低到22个月时的223 +/- 3μg/ mg。在滑液中发现的蛋白聚糖片段在2个月时测得为4.6 +/- 1μg/ ml，在22个月时增至37 +/- 2μg/ ml。在22个月时观察到的影像学变化包括胫骨和股骨的边缘骨赘，胫骨平台的软骨下骨的硬化，股骨dy囊肿和副韧带的钙化。组织学评估显示严重OA，Mankin评分为10.7 + / -在22个月大的动物中为0.5。相反，两个月大的动物没有组织学或放射学上可检测的病变。此处报道的研究结果表明，该模型中观察到的病变与人OA相似。豚鼠中骨关节炎的自发发展适合研究骨关节炎的发病机理和评估潜在的疾病改良剂。

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