Characterization of Platelet Abnormalities of Tester Moriyama (TM) Rats with Storage Pool Deficiency

Fujimori Hiroyuki; Ozaki Kiyokazu; Nomura Shosaku; Nishikawa Tetsu; Pan-Hou Hidemitsu; Nishimura Masahiko; Narama Isao

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Characterization of Platelet Abnormalities of Tester Moriyama (TM) Rats with Storage Pool Deficiency

机译：贮存池缺乏症的Tester Moriyama（TM）大鼠的血小板异常特征

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PlateletabnormalitiesofTesterMoriyama(TM)rats,whichhaveprolongedbleedingtimewithnormalplateletcount,werecharacterizedbycomparisonwiththoseoffawn-hooded(FH)ratswithplateletstoragepooldeficiency(SPD).Morphologically,thedensegranuleswerevirtuallylackinginplateletsfromTMandFHrats.PlateletsfromTMandFHratsaggregatedinresponsetoadenosinediphosphate(ADP),butfailedtohavesecondaryaggregation.Incontrast,plateletaggregationwascompletelyabsentinresponseto1to20#59157;gofcollagen/ml,althoughpartialaggregationwasobservedatthehigherdosageof50#59157;g/ml.NormalamountsofplateletmembraneglycoproteinsIIb/IIIawereexpressedinTMandFHrats,butplateletadenosinetriphosphate(ATP)andADPcontentswerelowerthanthoseinplateletsfromcontrolWistarrats.PlateletATP-to-ADPratioofTMandFHratswassignificantlyhigherthanthatofWistarrats.SerotonincontentinplateletsfromTMandFHratswas20to25%thatofWistarratplatelets.TheseresultssuggestedthatplateletabnormalitiesofTMratsareatypicalcharacteristicofplateletSPDandaresimilartothoseofFHrats,whicharegeneticallydifferentfromTMrats.Therefore,TMratsmayserveasausefulanimalmodelforthestudyofplateletSPD.

机译：PlateletabnormalitiesofTesterMoriyama（TM）大鼠，whichhaveprolongedbleedingtimewithnormalplateletcount，werecharacterizedbycomparisonwiththoseoffawn-罩住（FH）ratswithplateletstoragepooldeficiency（SPD）.Morphologically，thedensegranuleswerevirtuallylackinginplateletsfromTMandFHrats.PlateletsfromTMandFHratsaggregatedinresponsetoadenosinediphosphate（ADP），butfailedtohavesecondaryaggregation.Incontrast，plateletaggregationwascompletelyabsentinresponseto1to20＃59157; gofcollagen / ml时，althoughpartialaggregationwasobservedatthehigherdosageof50＃59157克/ ml.NormalamountsofplateletmembraneglycoproteinsIIb / IIIawereexpressedinTMandFHrats，butplateletadenosinetriphosphate（ATP）andADPcontentswerelowerthanthoseinplateletsfromcontrolWistarrats.PlateletATP到ADPratioofTMandFHratswassignificantlyhigherthanthatofWistarrats.SerotonincontentinplateletsfromTMandFHratswas20to25％thatofWistarratplatelets.TheseresultssuggestedthatplateletabnormalitiesofTMratsareatypicalcharacteristicofplateletSPDandaresimilartothoseofFHrats因此，TMrats可以作为有用的动物模型血小板SPD研究的有益工具。

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《Comparative Medicine》 |1998年第5期|共页
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Fujimori Hiroyuki; Ozaki Kiyokazu; Nomura Shosaku; Nishikawa Tetsu; Pan-Hou Hidemitsu; Nishimura Masahiko; Narama Isao;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Characterization of Platelet Abnormalities of Tester Moriyama (TM) Rats with Storage Pool Deficiency [J] . Fujimori Hiroyuki, Ozaki Kiyokazu, Nomura Shosaku, Comparative Medicine . 1998,第5期

机译：贮存池缺乏症的Tester Moriyama（TM）大鼠的血小板异常特征
2. Characterization of platelet abnormalities of tester moriyama (TM) rats with storage pool deficiency [J] . Hiroyuki Fujimori, Kiyokazu Ozaki, Shosaku Nomura Laboratory Animal Science . 1998,第5期

机译：藏池缺乏症的山间种（TM）大鼠血小板异常的特征
3. TM Rats: A Model for Platelet Storage Pool Deficiency [J] . Shuichi Hamada, Tetsu Nishikawa, Norihide Yokoi Experimental Animals . 1997,第3期

机译：TM大鼠：血小板贮存池缺乏症的模型
4. NUMERICAL INVESTIGATIONS OF A SPENT FUEL STORAGE POOL IN ABNORMAL CONDITIONS [C] . J-p Simoneau, B. Gaudron, Jerome Lavieville, International topical meeting on nuclear reactor thermal hydraulics . 2015

机译：异常条件下的燃油储存池的数值研究
5. Characterization of refrigerated platelets to improve storage time and function for transfusion. [D] . Reddoch, Kristin. 2015

机译：冷藏血小板的特征可以改善储存时间和输血功能。
6. Oral Squamous Cell Carcinoma Is Associated with a Low Thrombosis Risk Due to Storage Pool Deficiency in Platelets [O] . Pierre Haen, Lydie Crescence, Diane Mege, 2021

机译：口腔鳞状细胞癌与血小板储存池缺乏的血栓形成风险低有关
7. TM Rats: A Model for Platelet Storage Pool Deficiency. [O] . Shuichi HAMADA, Tetsu NISHIKAWA, Norihide YOKOI, 1997

机译：TM大鼠：血小板储存池缺乏模型。
8. Feasibility Study for Long-Term Storage and Hemostatic Effectiveness of Platelet Membrane Fractions Prepared from Human Platelet Concentrates [R] . McGill, M., Fugman, D. A., Vittorio, N., 1984

机译：人血小板浓缩液制备血小板膜组分的长期储存和止血效果的可行性研究

Characterization of Platelet Abnormalities of Tester Moriyama (TM) Rats with Storage Pool Deficiency

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