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Characterization of platelet abnormalities of tester moriyama (TM) rats with storage pool deficiency

机译：藏池缺乏症的山间种（TM）大鼠血小板异常的特征

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Platelet abnormalities of Tester Moriyama (TM) rats, which have prolonged bleeding time with normal platelet count, were characterized by comparison with those of fawn-hooded (FH) rats with platelet storage pool deficiency (SPD). Morphologically, the dense granules were virtually lacking in platelets from TM and FH rats. Platelets from TM and FH rats aggregated in response to adenosine diphosphate (ADP), but failed to have secondary aggregation. In contrast, platelet aggregation was completely absent in response to 1 to 20 #mu#g of collagen/ml, although partial aggregation was observed at the higher dosage of 50 #mu#g/ml. Normal amounts of platelet membrane glyeoproteins IIb/IIIa were expressed in TM and FH rats, but platelet adenosine triphosphate (ATP) and ADP contents were lower than those in platelets from control Wistar rats. Platelet ATP-to-ADP ratio of TM and FH rats was significantly higher than that of Wistar rats. Serotonin content in platelets from TM and FH rats was 20 to 25% that of Wistar rat platelets. These results suggested that platelet abnormalities of TM rats are a typical characteristic of platelet SPD and are similar to those of FH rats, which are genetically different from TM rats. Therefore, TM rats may serve as a useful animal model for the study of platelet SPD.
机译：通过与正常血小板计数的出血时间延长的Tester Moriyama（TM）大鼠的血小板异常特征进行比较，将其与具有血小板存储池缺乏症（SPD）的小鹿（FH）系大鼠比较。从形态上讲，TM和FH大鼠的血小板实际上缺乏致密颗粒。 TM和FH大鼠的血小板在对二磷酸腺苷（ADP）的反应下聚集，但没有二次聚集。相反，尽管在1至20μμg/ ml的胶原蛋白中观察到部分聚集，但对1至20μμg/ ml的胶原蛋白完全没有血小板聚集。正常量的血小板膜糖蛋白IIb / IIIa在TM和FH大鼠中表达，但血小板三磷酸腺苷（ATP）和ADP含量低于对照组Wistar大鼠的血小板。 TM和FH大鼠的血小板ATP / ADP比明显高于Wistar大鼠。 TM和FH大鼠血小板中的血清素含量为Wistar大鼠血小板的20％至25％。这些结果表明TM大鼠的血小板异常是血小板SPD的典型特征，并且与FH大鼠的血小板异常相似，后者与TM大鼠在遗传上有所不同。因此，TM大鼠可以作为研究血小板SPD的有用动物模型。

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