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Neuroimaging predictors of treatment response in anxiety disorders

机译:焦虑症治疗反应的神经影像预测因子

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Although several psychological and pharmacological treatment options are available for anxiety disorders, not all patients respond well to each option. Furthermore, given the relatively long duration of adequate treatment trials, finding a good treatment fit can take many months or longer. Thus, both clinicians and patients would benefit from the identification of objective pre-treatment measures that predict which patients will best respond to a given treatment. Recent studies have begun to use biological measures to help predict symptomatic change after treatment in anxiety disorders. In this review, we summarize studies that have used structural and functional neuroimaging measures to predict treatment response in obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), and social anxiety disorder (SAD). We note the limitations of the current studies and offer suggestions for future research. Although the literature is currently small, we conclude that pre-treatment neuroimaging measures do appear to predict treatment response in anxiety disorders, and future research will be needed to determine the relative predictive power of neuroimaging measures as compared to clinical and demographic measures.
机译:尽管焦虑症有几种心理和药物治疗选择,但并非所有患者对每种选择都反应良好。此外,鉴于适当的治疗试验需要相对较长的时间,因此找到合适的治疗方案可能需要数月或更长时间。因此,临床医师和患者都将从确定客观的治疗前措施中受益,这些措施可以预测哪些患者对给定的治疗方法最有效。最近的研究已经开始使用生物学手段来帮助预测焦虑症治疗后的症状变化。在这篇综述中,我们总结了使用结构和功能性神经影像学方法预测强迫症(OCD),创伤后应激障碍(PTSD),广泛性焦虑症(GAD)和社交焦虑症(SAD)的治疗反应的研究。我们注意到当前研究的局限性,并为以后的研究提供建议。尽管目前的文献很少,但我们得出的结论是,治疗前的神经影像学检查方法确实可以预测焦虑症的治疗反应,与临床和人口统计学方法相比,需要进一步的研究来确定神经影像学检测方法的相对预测能力。

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