Dense Cataract and Microphthalmia&#8212;New Spontaneous Mutation in BALB/c Mice

Kohale Kalidas; Ingle Arvind; Kelkar Asha; Parab Pradeep

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Dense Cataract and Microphthalmia—New Spontaneous Mutation in BALB/c Mice

机译：BALB / c小鼠中的密集白内障和小眼症新自发突变

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WedescribeanewspontaneousmutationinBALB/cmicethatcausesabnormalphenotype,suchascongenitalcataractandmicrophthalmia.Thisabnormalitywasfoundtobeinheritablebecauseoffspringwiththesameabnormalitywereproducedbybackcrossingtheabnormalmaletoitsnormalfemaleparent.Resultsofvariouscrossesmadetodeterminethemodeofinheritanceindicatedthatthisabnormalityisattributabletomutationofanautosomalrecessivegene.Slitlampexaminationofthemutanteyesrevealedtotallenticularopacity,disturbedtypicalirispattern,andabnormalpupillarymuscledevelopment.Histologicchangesinmutanteyesbetweengestationday13andpostnatalday1indicatedvariouseyeandlensabnormalities,includingmicrophthalmia;underdevelopediris,opticstalk,cornea,andretina;degeneratedlensfiberswithlostfibrillarstructure;andvacuolesofvarioussizesattheposteriorborderofthelens.Mildopacityofthelenswasfoundtoprogresswithageandbecamedenser,resemblingmaturecataract,andoccupyingthelenscompletelyattheageofsixtoeightweeks.We,therefore,temporarilydesignatedthisabnormalityasdensecataractandmicrophthalmia,withthegenesymboldcm.

机译：WedescribeanewspontaneousmutationinBALB / cmicethatcausesabnormalphenotype，suchascongenitalcataractandmicrophthalmia.Thisabnormalitywasfoundtobeinheritablebecauseoffspringwiththesameabnormalitywereproducedbybackcrossingtheabnormalmaletoitsnormalfemaleparent.Resultsofvariouscrossesmadetodeterminethemodeofinheritanceindicatedthatthisabnormalityisattributabletomutationofanautosomalrecessivegene.Slitlampexaminationofthemutanteyesrevealedtotallenticularopacity，disturbedtypicalirispattern，andabnormalpupillarymuscledevelopment.Histologicchangesinmutanteyesbetweengestationday13andpostnatalday1indicatedvariouseyeandlensabnormalities，includingmicrophthalmia; underdevelopediris，opticstalk，角膜，andretina; degeneratedlensfiberswithlostfibrillarstructure; andvacuolesofvarioussizesattheposteriorborderofthelens.Mildopacityofthelenswasfoundtoprogresswithageandbecamedenser，resemblingmaturecataract，andoccupyingthelenscompletelyattheageofsixtoeightweeks.We，因此，temporarilydesignatedthisabnormalityasdens伴有白内障和小眼症的基因征。

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《Comparative Medicine》 |2004年第3期|共页
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Kohale Kalidas; Ingle Arvind; Kelkar Asha; Parab Pradeep;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Dense cataract and microphthalmia - New spontaneous mutation in BALB/c mice [J] . Kohale K, Ingle A, Kelkar A, Comparative Medicine . 2004,第3期

机译：密集性白内障和小眼症-BALB / c小鼠中的新自发突变
2. Dense cataract and microphthalmia (dcm) in BALB/c mice is caused by mutations in the GJA8 locus [J] . Bakthavachalu B., Kalanke S., Galande S., Journal of genetics . 2010,第2期

机译：BALB / c小鼠中的密集白内障和小眼症（dcm）是由GJA8基因座中的突变引起的
3. Dense cataract and microphthalmia (dcm) in BALB/c mice is caused by mutations in the GJA8 locus [J] . Baskar Bakthavachalu, Sarmishtha Kalanke, Sanjeev Galande, Journal of Genetics . 2010,第2期

机译：BALB / c小鼠中的密集性白内障和小眼症（dcm）是由GJA8基因座中的突变引起的
4. First approach to the analysis of spontaneous activity of mice based on Permutation Entropy [C] . Carreno M.I., Lopez de Ipina Karmele, Beitia B., International Work Conference on Bio-inspired Intelligence . 2015

机译：基于排列熵的小鼠自发活动分析的第一种方法
5. Analysis of spontaneous mutation frequency and spectrum in cloned mice. [D] . Murphey, Patricia A. 2007

机译：克隆小鼠的自发突变频率和频谱分析。
6. SPONTANEOUS AMYLOIDOSIS IN DIFFERENTLY GROUPED AND TREATED DBA/2 BALB/c AND CBA MICE AND THYMUS FIBROSIS IN ESTROGEN-TREATED BALB/c MALES [O] . P. Ebbesen 1968

机译：不同分组和处理过的DBA / 2BALB / c和CBA小鼠的自发性淀粉样变性和雌激素处理过的BALB / c男性的胸腺纤维化
7. SPONTANEOUS AMYLOIDOSIS IN DIFFERENTLY GROUPED AND TREATED DBA/2, BALB/c, AND CBA MICE AND THYMUS FIBROSIS IN ESTROGEN-TREATED BALB/c MALES [O] . Ebbesen, P. 1968

机译：不同分组和处理过的DBA / 2，BALB / c和CBA小鼠的自发性淀粉样变性和雌激素处理过的BALB / c男性的胸腺纤维化
8. Development of Spontaneous Mammary Tumors in BALB/c-p53+/-Mice: Detection of Early Genetic Alterations and the Mapping of BALB/c Susceptibility Genes [R] . Hill, X. , Jerry, J. 2005

机译：BaLB / c-p53 +/-小鼠自发性乳腺肿瘤的发展：早期遗传改变的检测和BaLB / c易感基因的定位

Dense Cataract and Microphthalmia&#8212;New Spontaneous Mutation in BALB/c Mice

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Dense Cataract and Microphthalmia—New Spontaneous Mutation in BALB/c Mice