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首页> 外文期刊>Comparative and functional genomics >Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer
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Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer

机译：法呢基-二磷酸法呢基转移酶1基因启动子中的SNP rs2645429与肺癌易感性的关系

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Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors. One of the enzymes involved in the mevalonate pathway is FDFT1. Different variants of this gene are involved in the risk of suffering various diseases. The present study examined the relationship between FDFT1 rs2645429 polymorphism and the risk of nonsmall cell lung cancer (NSCLC) in a population from southern Iran. Method. The genotypes of rs2645429 polymorphism of FDFT1 gene were examined in 95 samples 34 patients with NSCLC and 61 healthy individuals by RFLP method. Results. The results of this study indicated that C allele of this polymorphism was effectively associated with the risk of NSCLC in the Iranian population ( valuea??=a??0.023; ORa??=a??2.71; 95% CIa??=a??1.12a??6.59) and CC genotype has significant relation with susceptibility to NSCLC ( valuea??=a??0.029; ORa??=a??3.02; 95% CIa??=a??1.09a??8.39). This polymorphism is located in the promoter region FDFT1 gene, and CC genotype may increase the activity of this promoter. This study also found a significant relationship between C allele and metastatic status. C allele was more common in NSCLC patients. (). Conclusion. C allele of FDFT1 rs2645429 polymorphism gene can be a risk factor for NSCLC, whereas T allele probably has a low protective role.
机译：背景和目的。甲羟戊酸途径是使用乙酰辅酶A产生固醇和类异戊二烯的主要代谢途径之一。这些化合物可以有效地促进肿瘤的生长和发展。甲羟戊酸途径中涉及的酶之一是FDFT1。该基因的不同变体涉及患各种疾病的风险。本研究检查了伊朗南部人群中FDFT1 rs2645429多态性与非小细胞肺癌（NSCLC）风险之间的关系。方法。应用RFLP方法检测了95例34例NSCLC患者和61例健康个体的FDFT1基因rs2645429基因多态性。结果。这项研究的结果表明，这种多态性的C等位基因与伊朗人群中NSCLC的风险有效相关（值a ?? = a ?? 0.023; ORa ?? = a ?? 2.71; 95％CIa ?? = a）。 ≥1.12a≥6.59）和CC基因型与对NSCLC的易感性有显着相关性（值a≥＝a≥0.029;ORa≥＝a≥3.02; 95％CIa≥＝a≥1.09a≥1.0。 8.39）。这种多态性位于启动子区域FDFT1基因中，而CC基因型可能会增加该启动子的活性。该研究还发现C等位基因与转移状态之间存在显着关系。 C等位基因在NSCLC患者中更为常见。 （）。结论。 FDFT1 rs2645429多态性基因的C等位基因可能是NSCLC的危险因素，而T等位基因的保护作用可能很低。

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