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首页> 外文期刊>International Journal of Genomics >Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer
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Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer

机译：与肺癌易感性肺癌的法牛排 - 二磷酸磷酸盐酶1基因启动子的SNP RS2645429

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摘要

Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors. One of the enzymes involved in themevalonate pathway is FDFT1. Different variants of this gene are involved in the risk of suffering various diseases. The present study examined the relationship between FDFT1 rs2645429 polymorphism and the risk of nonsmall cell lung cancer (NSCLC) in a population from southern Iran. Method. The genotypes of rs2645429 polymorphism of FDFT1 gene were examined in 95 samples: 34 patients with NSCLC and 61 healthy individuals by RFLP method. Results. The results of this study indicated that C allele of thispolymorphism was effectively associated with the risk of NSCLC in the Iranian population (p value = 0.023; OR = 2.71; 95% CI= 1.12-6.59) and CC genotype has significant relation with susceptibility to NSCLC (p value = 0.029; OR = 3.02; 95% CI = 1.09-8.39). This polymorphism is located in the promoter region FDFT1 gene, and CC genotype may increase the activity of this promoter. This study also found a significant relationship between C allele and metastatic status. C allele was more common in NSCLC patients, (p = 0.04). Conclusion. C allele of FDFT1 rs2645429 polymorphism gene can be a risk factor for NSCLC, whereas T allele probably has a low protective role.
机译：背景和目的。甲戊二醇酯途径是使用乙酰-CoA产生甾醇和异戊二烯的主要代谢途径之一。这些化合物可以有效地在肿瘤的生长和发育中。参与Theoevalonate途径的酶之一是FDFT1。该基因的不同变体涉及患有各种疾病的风险。本研究检测了FDFT1 RS2645429多态性与来自南部南部人口中的Nonsmall细胞肺癌（NSCLC）之间的关系。方法。在95个样品中检查了FDFT1基因的Rs2645429的基因型：34例NSCLC和61例通过RFLP方法患者。结果。该研究的结果表明，该研究的C等位值有效地与伊朗人群中NSCLC的风险有效（P值= 0.023;或= 2.71; 95％CI = 1.12-6.59）和CC基因型与易感性有重大关系NSCLC（P值= 0.029;或= 3.02; 95％CI = 1.09-8.39）。该多态性位于启动子区FDFT1基因中，CC基因型可能增加该启动子的活性。本研究还发现了C等位基因和转移状态之间的重要关系。 C等位基因在NSCLC患者中更常见（P = 0.04）。结论。 C FDFT1 RS2645429的等位基因多态性基因可以是NSCLC的危险因素，而T等位基因可能具有低的保护作用。

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  • 来源
    《International Journal of Genomics》 |2018年第1期|共7页
  • 作者

    Mehdi Dehghani; Zahra Samani; Hassan Abidi;

  • 作者单位

    Hematology and Medical Oncology Department Hematology Research Center Shiraz University of Medical Sciences Shiraz Iran;

    Cellular and Molecular Research Center Yasuj University of Medical Sciences Yasuj Iran;

    Cellular and Molecular Research Center Yasuj University of Medical Sciences Yasuj Iran;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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