Urinary Biomarkers for Monitoring Disease Progression in the Han:SPRD-cy Rat Model of Autosomal-Dominant Polycystic Kidney Disease

Wiedmeyer Charles E; Royal Angela B

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Urinary Biomarkers for Monitoring Disease Progression in the Han:SPRD-cy Rat Model of Autosomal-Dominant Polycystic Kidney Disease

机译：监测汉族常染色体显性多囊肾疾病模型的疾病进展的尿液生物标志物

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TheHan:SRPD-cyratisawell-recognizedmodelofhumanautosomal-dominantpolycystickidneydisease.Thediseaseischaracterizedbythedevelopmentofprogressiverenalcysts,leadingtodecliningrenalfunction.Diseaseprogressiontypicallyismonitoredbymeasurementofplasmaureaconcentration.Althoughplasmaureamaybeanadequatemeasureofoverallrenalfunction,urinarybiomarkerscapableofaccuratelymonitoringdiseaseprogressionmaybeequallyuseful.ThegoalofthisstudywastoassessseveralurinarybiomarkersaspotentialmarkersofdiseaseprogressioninmaleandfemaleHan:SPRD-cyrats.Thesebiomarkerswerecomparedwithchangesinplasmaureaconcentrationandmorphometricchangesasthediseaseprogressed.UrinaryactivityofN-acetyl-#59137;-D-glucosaminidaseandconcentrationof#945;-glutathioneS-transferaseweremeasuredasmarkersofproximaltubulardysfunction,glutathioneS-transferaseYb1asadistaltubularmarker,andcollagenIVasabiomarkerforglomerularlesions.Urinaryalbuminwasusedasbiomarkerofglomerularorproximaltubularlesions.Albuminuriaincreasedinmaleratsasthediseaseprogressed,correlatingwithincreasingplasmaureaandmorphologicchanges.Urineconcentrationsof#945;-glutathioneS-transferasedecreasedsignificantlyinthemaleheterozygoticcomparedwithwildtyperatsinthelaterstagesofthedisease.UrinaryconcentrationsofglutathioneS-transferaseYb1andcollagenIVandactivityofN-acetyl-#59137;-D-glucosaminidasedidnotchangeduringdiseaseprogression.Measurementofurinaryalbuminandconcentrationsof#945;-glutathioneS-transferasemaybeusefulformonitoringdiseaseprogressioninthemaleHan:SPRD-cyratmodelinfutureexperiments.

机译：TheHan：SRPD-cyratisawell-recognizedmodelofhumanautosomal-dominantpolycystickidneydisease.Thediseaseischaracterizedbythedevelopmentofprogressiverenalcysts，leadingtodecliningrenalfunction.Diseaseprogressiontypicallyismonitoredbymeasurementofplasmaureaconcentration.Althoughplasmaureamaybeanadequatemeasureofoverallrenalfunction，urinarybiomarkerscapableofaccuratelymonitoringdiseaseprogressionmaybeequallyuseful.ThegoalofthisstudywastoassessseveralurinarybiomarkersaspotentialmarkersofdiseaseprogressioninmaleandfemaleHan：SPRD-cyrats.Thesebiomarkerswerecomparedwithchangesinplasmaureaconcentrationandmorphometricchangesasthediseaseprogressed.UrinaryactivityofN乙酰＃59137; -D-glucosaminidaseandconcentrationof＃945; -glutathioneS-transferaseweremeasuredasmarkersofproximaltubulardysfunction，谷胱甘肽-transferaseYb1asadistaltubularmarker尿白蛋白被用作肾小球或近端肾小管病变的生物标志物。白蛋白尿增加了雌性大鼠的变性病。 essed，correlatingwithincreasingplasmaureaandmorphologicchanges.Urineconcentrationsof＃945; -glutathioneS-transferasedecreasedsignificantlyinthemaleheterozygoticcomparedwithwildtyperatsinthelaterstagesofthedisease.UrinaryconcentrationsofglutathioneS-transferaseYb1andcollagenIVandactivityofN乙酰＃59137; -D-glucosaminidasedidnotchangeduringdiseaseprogression.Measurementofurinaryalbuminandconcentrationsof＃945; -glutathioneS-transferasemaybeusefulformonitoringdiseaseprogressioninthemaleHan：SPRD-cyratmodelinfutureexperiments。

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《Comparative Medicine》 |2010年第6期|共页
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Wiedmeyer Charles E; Royal Angela B;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Urinary Biomarkers for Monitoring Disease Progression in the Han:SPRD-cy Rat Model of Autosomal-Dominant Polycystic Kidney Disease [J] . Wiedmeyer Charles E., Royal Angela B. . Comparative Medicine . 2010,第6期

机译：监测汉族常染色体显性多囊肾疾病模型的疾病进展的尿液生物标志物
2. Cyclooxygenase product inhibition with acetylsalicylic acid slows disease progression in the Han:SPRD-Cy rat model of polycystic kidney disease [J] . Naser H.M. Ibrahim, Melanie Gregoire, Jessay G. Devassy, Prostaglandins and Other Lipid Mediators . 2015,第Null期

机译：乙酰水杨酸对环氧合酶产物的抑制作用可减缓Han：SPRD-Cy大鼠多囊肾疾病模型的疾病进展
3. Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease. [J] . Sankaran D, Bankovic-Calic N, Ogborn MR, American Journal of Physiology . 2007,第3期

机译：在患有遗传性肾脏疾病的Han：SPRD-cy大鼠中，选择性的COX-2抑制作用显着减慢了疾病的进展，并减弱了类前列腺素的产生。
4. Urinary Exosomes; A Source Of Biomarkers And Novel Diagnostics For Polycystic Kidney Disease [C] . Christopher J. Ward, Marie C. Hogan, Roman M. Zenka, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：尿表;多囊肾病的生物标志物和新型诊断源
5. Feeding Soy Protein Isolate and/or Omega-3 Polyunsaturated Fatty Acids on the Spleen-Liver Axis in a Female Rat Model of Autosomal Recessive Polycystic Kidney Disease with Liver Steatosis. [D] . Gibson, Lauren. 2016

机译：在常染色体隐性隐性多囊肾病伴肝脏脂肪变性的雌性大鼠模型中，在脾肝轴上饲喂大豆分离蛋白和/或Omega-3多不饱和脂肪酸。
6. Urinary Biomarkers for Monitoring Disease Progression in the Han:SPRD-cy Rat Model of Autosomal-Dominant Polycystic Kidney Disease [O] . Charles E Wiedmeyer, Angela B Royal 2010

机译：监测汉族常染色体显性多囊肾疾病模型的疾病进展的尿液生物标志物
7. A comparative study of three kidney biomarker tests in autosomal-dominant polycystic kidney disease [O] . Casal J. Antonio, Hermida Jesús, Lens Xosé M., 2005

机译：三种常染色体显性多囊肾疾病肾脏生物标志物检测方法的比较研究

Urinary Biomarkers for Monitoring Disease Progression in the Han:SPRD-cy Rat Model of Autosomal-Dominant Polycystic Kidney Disease

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