Neuroendocrine (ECL Cell) Differentiation of Spontaneous Gastric Carcinomas of Cotton Rats (Sigmodon hispidus)

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Neuroendocrine (ECL Cell) Differentiation of Spontaneous Gastric Carcinomas of Cotton Rats (Sigmodon hispidus)

机译：棉花大鼠自发胃癌的神经内分泌（ECL细胞）分化（Sigmodon hispidus）

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BackgroundandPurpose:Femaleinbredcottonratsdevelopadenocarcinomasintheoxynticmucosa.Sinceafemalepreponderanceistypicalforenterochromaffin-like(ECL)celltumors,weexaminedsuchtumorsforECLcells.GastrinplaysadecisiveroleinECLcelltumorigenesis,sobloodgastrinconcentrationandgastricmucosalpHweremeasured.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Thestomachsfromsixfemalecottonrats(6to8monthsold)werestudiedhistologically,andateuthanasia,gastricmucosalpHwasdetermined.Euthanasiawasperformedon15otherfemalecottonratsofsimilaragefordeterminationofbloodgastrinvaluesbyradioimmunoassay(RIA)andgastricmucosalpH.Ratswereclassifiedmacroscopicallytohavenormalorthickoxynticmucosa,withorwithouttumor.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Amongthesixcottonratsstudiedhistologically,two6-month-oldratshadnormalandtwoothershadthickgastricmucosa,whereastwo8-month-oldratshadthickmucosawithtumors.TheECLcellsweremarkedlyhyperplasticinallratswiththickmucosa,andECLcellswerefoundintheneoplasticparenchyma.Allcottonratswithnormal-appearinggastricmucosahadpH2.5,whereas14ratswiththickmucosahadpH3.1andhypergastrinemia.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:GastrinmayplayamajorroleinECLcellhyperplasiaand,perhaps,inadenocarcinomagenesis.

机译：BackgroundandPurpose：Femaleinbredcottonratsdevelopadenocarcinomasintheoxynticmucosa.Sinceafemalepreponderanceistypicalforenterochromaffin样（ECL）celltumors，weexaminedsuchtumorsforECLcells.GastrinplaysadecisiveroleinECLcelltumorigenesis，sobloodgastrinconcentrationandgastricmucosalpHweremeasured 方法：Thestomachsfromsixfemalecottonrats（6to8monthsold）werestudiedhistologically，。andateuthanasia，gastricmucosalpHwasdetermined.Euthanasiawasperformedon15otherfemalecottonratsofsimilaragefordeterminationofbloodgastrinvaluesbyradioimmunoassay（RIA）andgastricmucosalpH.Ratswereclassifiedmacroscopicallytohavenormalorthickoxynticmucosa，withorwithouttumor 结果：Amongthesixcottonratsstudiedhistologically，two6个月oldratshadnormalandtwoothershadthickgastricmucosa，whereastwo8-伴有肿瘤的月大的大鼠阴影浓厚的粘膜。所有患有粘膜厚的大鼠的ECL细胞明显增生，而ECL细胞发现整形的实质性组织。所有出现正常胃粘膜pH值<2.5的纯棉大鼠，其中有粘膜粘膜pH值> 3.1且高胃泌素血症的14只大鼠。

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《Comparative Medicine》 |1999年第3期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Neuroendocrine (ECL cell) differentiation of spontaneous gastric carcinomas of cotton rats (Sigmodon hispidus) [J] . Helge L. Waldum, Hege Rorvik, Sture Falkmer Laboratory Animal Science . 1999,第3期

机译：棉花大鼠自发性胃癌的神经内分泌（ECL细胞）分化（Sigmodon hispidus）
2. Catastrophic decline of a high-density population of hispid cotton rats (Sigmodon hispidus) in central Oklahoma [J] . Clark JE, Hellgren EC, Jorgensen EE The Southwestern Naturalist . 2003,第3期

机译：俄克拉荷马州中部高密度棉山羊大鼠（Sigmodon hispidus）的灾难性衰退
3. Range Expansion of Sigmodon hispidus (Hispid Cotton Rat) into Reclaimed Coal Surface-mines in Southeastern Kentucky [J] . Slabach Brittany L., Krupa James J. Southeastern naturalist . 2018,第4期

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4. The Japanese Cotton Rat Develops Spontaneously an ECL Cell Derived Gastric Carcinoma [C] . H.L. Waldum, R. Fossmark, T.C. Martinsen, International Gastric Cancer Congress . 2005

机译：日本棉花大鼠自发地发展ECL细胞衍生的胃癌
5. Toxicity risks associated with petrochemical wastes; based on resident cotton rats (Sigmodon hispidus). [D] . Kim, Soochong. 1999

机译：与石化废物有关的毒性风险；基于常驻棉鼠（Sigmodon hispidus）。
6. Extent of Measles Virus Spread and Immune Suppression Differentiates between Wild-Type and Vaccine Strains in the Cotton Rat Model (Sigmodon hispidus) [O] . Joanna Pfeuffer, Karen Püschel, Volker ter Meulen, 2003

机译：棉鼠模型（Sigmodon hispidus）的麻疹病毒传播程度和免疫抑制程度在野生型和疫苗株之间有所区别。
7. Spontaneous ECLomas in cotton rats (Sigmodon hispidus): tumours occurring in hypoacidic/hypergastrinaemic animals with normal parietal cells [O] . G. Cui 2000

机译：棉花大鼠的自发卵巢（Sigmodon Hispidus）：肿瘤发生在低兴奋/高纤维动物患有正常的椎管细胞中
8. Isoagglutination and Heteroagglutination of the Erythrocytes of the Cotton Rat, Sigmodon Hispidus Texianus, and the Reactions of Cotton Rat Plasmas with Human Erythrocytes. [R] . Leone, C. A., Dolyak, F., Truffelli, G. T. 1952

机译：棉花鼠sigtron Hispidus Texianus红细胞的异凝集和杂交，以及棉鼠血浆与人红细胞的反应。

Neuroendocrine (ECL Cell) Differentiation of Spontaneous Gastric Carcinomas of Cotton Rats (Sigmodon hispidus)

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