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Evolutionary Conservation Levels of Subunits of Histone-Modifying Protein Complexes in Fungi

机译：真菌中组蛋白修饰蛋白复​​合物亚基的进化保守水平

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摘要

Eukaryotes possess a variety of histone-modifying protein complexes. Generally, a histone-modifying protein complex consists of multiple subunits, that is, a catalytic subunit and the associated subunits. In this study, I analyzed 62 and 48 subunits of the histone-modifying protein complexes ofSaccharomyces cerevisiaeandSchizosaccharomyces pombe, respectively. The evolutionary conservation levels of the 110 subunits were measured. The measurements revealed that the conservation levels of the catalytic subunits are significantly higher than those of the associated subunits of the histone acetyltransferase and deacetylase complexes; however, the conservation level of the catalytic subunits is similar to that of the associated subunits of the histone methyltransferase complexes. Thus, in the fungal histone acetylation and deacetylation systems, the catalytic subunits of histone-modifying protein complexes are conserved and the associated subunits are evolutionary lineage-specific. In contrast, in the fungal histone methylation system, both the catalytic and the associated subunits are evolutionary lineage-specific.
机译：真核生物具有多种组蛋白修饰蛋白复​​合物。通常，组蛋白修饰蛋白复​​合物由多个亚基组成，即催化亚基和相关的亚基。在这项研究中，我分别分析了酿酒酵母和粟酒裂殖酵母的组蛋白修饰蛋白复​​合物的62个和48个亚基。测量了110个亚基的进化保守水平。测量表明，催化亚基的保守水平明显高于组蛋白乙酰转移酶和脱乙酰基酶复合物的相关亚基的保守水平。然而，催化亚基的保守水平与组蛋白甲基转移酶复合物的相关亚基的保守水平相似。因此，在真菌组蛋白乙酰化和脱乙酰化系统中，组蛋白修饰蛋白复​​合物的催化亚基是保守的，而相关的亚基是进化谱系特异性的。相反，在真菌组蛋白甲基化系统中，催化亚基和相关亚基都是进化谱系特异性的。

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