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Lymphosarcoma in the Laboratory Woodchuck (Marmota monax)

机译:实验室土拨鼠的淋巴肉瘤(早獭)

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From1979to1999,28casesoflymphosarcomawereidentifiedintheCornellUniversitywoodchuckcolony(prevalencerate:152/100,000/yr).Theprevalenceoflymphosarcomawassimilarinwoodchucksnotinfectedwiththewoodchuckhepatitisvirus(WHV)andinchroniccarriersofWHV.Males(13)andfemales(15)alikewereaffected(mean±SDage4.7±2.92years;range,0.5to9years).Onthebasisofthemajororgansysteminvolved,woodchucklymphosarcomawasclassifiedasmulticentric(12cases,43%),alimentary(5cases,18%),cranialmediastinal(5cases,18%),andmiscellaneous(6cases,21%).Acutaneousformwasnotobserved.MorphologiccriteriasimilartothoseoftheKielclassificationwereusedforlightmicroscopicclassification.AllKielcategories#8212;excepttheimmunoblasticform#8212;werefound:17cases(61%)werecentroblastic,and6werelymphocytic(21%).Othercategories(centrocyticandplasmacytoid)wererecognizedlessfrequently.Immunophenotypingof27casesrevealed15(56%)Bcell(CD3supxmlns="http://pub2web.metastore.ingenta.coms/"#8722;/sup/CD79asupxmlns="http://pub2web.metastore.ingenta.coms/"+/suporCD3supxmlns="http://pub2web.metastore.ingenta.coms/"#8722;/sup/BLA.36supxmlns="http://pub2web.metastore.ingenta.coms/"+/sup),7(26%)Tcell(CD3supxmlns="http://pub2web.metastore.ingenta.coms/"+/sup/CD79asupxmlns="http://pub2web.metastore.ingenta.coms/"#8722;/sup/BLA.36supxmlns="http://pub2web.metastore.ingenta.coms/"#8722;/sup),and5(18%)non-Tnon-Bcell(CD3supxmlns="http://pub2web.metastore.ingenta.coms/"#8722;/sup/CD79asupxmlns="http://pub2web.metastore.ingenta.coms/"#8722;/sup/BLA.36supxmlns="http://pub2web.metastore.ingenta.coms/"#8722;/sup)lymphosarcomas.Lymphosarcomainwoodchucksdevelopsatahigherratethanthatobservedinhumansorcompanionanimals,andWHVinfectionhasnoeffectonprevalence.TheanatomicandKielclassificationusedindomesticspeciesalsocanbeusedinwoodchucks.Commerciallyavailable#945;-CD3,#945;-CD79a,and#945;-BLA.36antibodieswereusefulforimmunophenotypingwoodchucklymphosarcomas.
机译:From1979to1999,28casesoflymphosarcomawereidentifiedintheCornellUniversitywoodchuckcolony(prevalencerate:152 / 100,000 /年).Theprevalenceoflymphosarcomawassimilarinwoodchucksnotinfectedwiththewoodchuckhepatitisvirus(WHV)andinchroniccarriersofWHV.Males(13)andfemales(15)alikewereaffected(平均值±SDage4.7±2.92年;范围,0.5to9years).Onthebasisofthemajororgansysteminvolved,woodchucklymphosarcomawasclassifiedasmulticentric(12案件, 43%),消化性(5例,18%),颅内纵隔(5例,18%)和其他(6例,21%)。未观察到皮肤形态。形态学标准类似于基尔分类法,用于光学显微镜分类。所有基尔分类法#8212均由塑料制成,第8612号和16号(免疫重组): (21%)。其他类别(中心细胞和浆细胞样)很少被人认识。免疫分型27例显示15(56%)Bcell(CD3 #8722; / CD79a + 或CD3 #8722; /BLA.36 + ),7(26%)Tcell(CD3 + / CD79a #8722; /BLA.36 #8722; )和5(18%)non-Tnon-Bcell(CD3 #8722; / CD79a #8722; /BLA.36 #8722; )淋巴肉瘤。Lymphosarcomainwoodcucks的发展速度要高于观察人类或伴侣的动物,并且对WHV的感染对患病率没有任何影响。也可以使用945年代的CD或CD的木虱来对CD进行分析,并与CD一起使用。

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