• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical & developmental immunology. >Interleukin-19 in Breast Cancer
【24h】

Interleukin-19 in Breast Cancer

机译：IL-19在乳腺癌中的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Inflammatory cytokines within the tumor microenvironment are linked to progression in breast cancer. Interleukin- (IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis. IL-19 is expressed in several types of tumor cells, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung and invasive duct carcinoma of the breast. In breast cancer, IL-19 expression is correlated with increased mitotic figures, advanced tumor stage, higher metastasis, and poor survival. The mechanisms of IL-19 in breast cancer have recently been explored both in vitro and in vivo . IL-19 has an autocrine effect in breast cancer cells. It directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression, which suggests that IL-19 is a prognostic marker in breast cancer and that antagonizing IL-19 may have therapeutic potential.
机译：肿瘤微环境中的炎性细胞因子与乳腺癌的进展有关。白介素-（IL-）19是IL-10家族的一部分，可导致多种疾病和病症，例如哮喘，内毒素性休克，尿毒症，牛皮癣和类风湿性关节炎。 IL-19在几种类型的肿瘤细胞中表达，尤其是在皮肤的鳞状细胞癌，舌癌，食道癌和肺癌以及乳腺浸润性导管癌中。在乳腺癌中，IL-19的表达与有丝分裂图的增加，肿瘤的晚期分期，较高的转移和不良的生存率相关。 IL-19在乳腺癌中的机制最近已在体内外进行了探索。 IL-19在乳腺癌细胞中具有自分泌作用。它直接促进增殖和迁移，并间接提供肿瘤进展的微环境，这表明IL-19是乳腺癌的预后标志物，拮抗IL-19可能具有治疗潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号