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Review of the Early Diagnoses and Assessment of Rejection in Vascularized Composite Allotransplantation

机译：血管化复合同种异体移植的早期诊断及排斥反应评估

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The emerging field of vascular composite allotransplantation (VCA) has become a clinical reality. Building upon cutting edge understandings of transplant surgery and immunology, complex grafts such as hands and faces can now be transplanted with success. Many of the challenges that have historically been limiting factors in transplantation, such as rejection and the morbidity of immunosuppression, remain challenges in VCA. Because of the accessibility of most VCA grafts, and the highly immunogenic nature of the skin in particular, VCA has become the focal point for cross-disciplinary approaches to developing novel approaches for some of the most challenging immunological problems in transplantation, particularly the early diagnoses and assessment of rejection. This paper provides a historically oriented introduction to the field of organ transplantation and the evolution of VCA.
机译：血管复合同种异体移植（VCA）的新兴领域已成为临床现实。基于对移植手术和免疫学的前沿了解，现在可以成功移植复杂的移植物，例如手和脸。历史上一直限制移植因素的许多挑战，例如排斥反应和免疫抑制的发病率，仍然是VCA中的挑战。由于大多数VCA移植物的可及性，尤其是皮肤的高度免疫原性，VCA已成为跨学科研究方法的重点，以针对移植中某些最具挑战性的免疫学问题开发新方法，尤其是早期诊断和拒绝评估。本文对器官移植和VCA的发展提供了历史性的介绍。

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