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首页> 外文期刊>Clinical & developmental immunology. >Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B
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Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B

机译：干扰素α对慢性乙型肝炎患者外周血单个核细胞中hTERT mRNA表达的影响

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Cell division is closely related to telomerase activity (hTERT mRNA). Lower expression of lymphocitic hTERT mRNA may easily cause cell aging, which is not beneficial to maintaining a durable lymphocyte division. To date, there is no study to investigate IFN α therapy on hTERT mRNA expression in PBMCs of patients with chronic hepatitis B (CHB). We quantitatively detected hTERT mRNA from study subjects and made each hTERT mRNA normalized (NhTERT mRNA). Mean NhTERT mRNA level was lower in either CHB group, but it significantly increased in IFN α -treated group compared with CHB control group, and a longer duration of IFN α therapy could increase the level. Moreover, the mean NhTERT mRNA in subgroup with HBeAg loss was significantly higher than that in subgroup without. NhTERT mRNA was markedly correlated with CD3~(+)T lymphocyte count and CD4~(+)/CD8~(+)ratio. The results showed that IFN α therapy could upregulate the expression of hTERT mRNA in PBMCs.
机译：细胞分裂与端粒酶活性（hTERT mRNA）密切相关。淋巴细胞hTERT mRNA的较低表达可能容易引起细胞衰老，这不利于维持持久的淋巴细胞分裂。迄今为止，尚无研究IFNα治疗对慢性乙型肝炎（CHB）患者PBMC中hTERT mRNA表达的研究。我们从研究对象中定量检测了hTERT mRNA，并使每个hTERT mRNA标准化（NhTERT mRNA）。在任何一个CHB组中，平均NhTERT mRNA水平均较低，但与CHB对照组相比，在IFNα治疗组中NhTERT mRNA水平显着升高，并且更长的IFNα治疗时间可提高该水平。此外，HBeAg缺失亚组的平均NhTERT mRNA显着高于无HBeAg的亚组。 NhTERT mRNA与CD3〜（+）T淋巴细胞计数和CD4〜（+）/ CD8〜（+）比率显着相关。结果表明，干扰素α治疗可上调PBMC中hTERT mRNA的表达。

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