Effect of Respiratory Tract Disease on Pharmacokinetics of Tilmicosin in Rats

首页> 外文期刊>Comparative Medicine >Effect of Respiratory Tract Disease on Pharmacokinetics of Tilmicosin in Rats

【24h】

Effect of Respiratory Tract Disease on Pharmacokinetics of Tilmicosin in Rats

机译：呼吸道疾病对Tilmicosin大鼠药代动力学的影响

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundandPurpose:Inrats,murinerespiratorymycoplasmosisiscausedbyMycoplasmapulmonis.Tilmicosin,amacrolideantibiotic,hasgoodtissuepenetrationandreacheshighconcentrationinthelungs.Therefore,amodelforstudyingtheeffectsofdiseaseonpharmacokineticsoftilmicosinwasdeveloped,usingLEWrats.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Seventy-twoLEWratswereassignedatrandomtotwogroups:onegroupwasinoculatedwithM.pulmonis,andtheotherservedasanuninoculatedcontrolgroup.Onpostinoculationday31,allratsreceivedasingledoseoftilmicosin(20mg/kgofbodyweight,subcutaneously).brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Concentrationoftilmicosininthelungsofbothgroupsofratswassignificantlyhigherthanserumtilmicosinconcentrationatalltimes.Infectedratshadsignificantlyhigherlungtilmicosinconcentrationthandidnoninfectedrats.NocorrelationwasfoundbetweenpHofthelungsandtilmicosinconcentrationinthelungsineithertreatmentgroup,nordidtreatmenthaveanyeffectonpHofthemuscle.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusion:Tilmicosinaccumulatesinthelungs,andinfection/inflammationfurtherimprovesitstissuepenetration.

机译：BackgroundandPurpose：Inrats，murinerespiratorymycoplasmosisiscausedbyMycoplasmapulmonis.Tilmicosin，amacrolideantibiotic，hasgoodtissuepenetrationandreacheshighconcentrationinthelungs.Therefore，amodelforstudyingtheeffectsofdiseaseonpharmacokineticsoftilmicosinwasdeveloped，usingLEWrats 方法：七十twoLEWratswereassignedatrandomtotwogroups：onegroupwasinoculatedwithM。 pulmonis，andtheotherservedasanuninoculatedcontrolgroup.Onpostinoculationday31，allratsreceivedasingledoseoftilmicosin（20毫克/ kgofbodyweight，皮下）结果：Concentrationoftilmicosininthelungsofbothgroupsofratswassignificantlyhigherthanserumtilmicosinconcentrationatalltimes.Infectedratshadsignificantlyhigherlungtilmicosinconcentrationthandidnoninfectedrats.NocorrelationwasfoundbetweenpHofthelungsandtilmicosinconcentrationinthelungsineithertreatmentgroup，nordidtreatmenthaveanyeffectonpHofthemuscle < brxmlns =“ ht结论：Tilmicosin会积聚许多内脏，而感染/炎症会进一步促进其穿透组织。tp：//pub2web.metastore.ingenta.coms/“>

著录项

来源
《Comparative Medicine》 |1999年第3期|共页
作者

展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类畜牧、动物医学、狩猎、蚕、蜂;
关键词

相似文献

外文文献
中文文献
专利

1. Effect of respiratory tract disease on pharmacokinetics of tilmicosin in rats. [J] . Modric S, Webb AI, Davidson M Laboratory Animal Science . 1999,第3期

机译：呼吸道疾病对替米考星在大鼠体内药代动力学的影响。
2. Effects of nasal instillation of a nitric oxide-releasing solution or parenteral administration of tilmicosin on the nasopharyngeal microbiota of beef feedlot cattle at high-risk of developing respiratory tract disease [J] . E. Timsit, M. Workentine, T. Crepieux, Research in Veterinary Science . 2017,第期

机译：鼻内滴注的鼻腔滴注液滴注对脑脊液牛粪牛粪微生物的肠胃外施用，高危发育呼吸道疾病
3. Effects of tilmicosin on acute undifferentiated respiratory tract disease in newly arrived feedlot cattle. [J] . Vogel GJ, Laudert SB, Zimmermann A, Journal of the American Veterinary Medical Association . 1998,第12期

机译：替米考星对新到达饲养场牛急性未分化呼吸道疾病的影响。
4. Effectiveness of tilmicosin phosphate (Pulmotil~R AC) for controlling respiratory disease associated with Mycoplasma hyopneumoniae in swine in the presence of porcine reproductive and respiratory synd [C] . Daniel Ivers, Chris Puis, Tom Weber, Annual^Meeting of the American^Association^of^Swine^Veterinarians. . 2016

机译：猪繁殖与呼吸道同步术治疗猪磷酸盐藓疫苗病毒治疗呼吸道疾病患者
5. Reovirus 1/L and influenza A infection of the upper and lower respiratory tracts: A paradigm for studies of the respiratory tract in the context of mucosal immunity. [D] . Thompson, Amy Hodson. 1998

机译：呼肠孤病毒1 / L和上下呼吸道的甲型流感感染：在粘膜免疫的背景下研究呼吸道的范例。
6. Continuous vs. intermittent cefotaxime administration in patients with chronic obstructive pulmonary disease and respiratory tract infections: pharmacokinetics/pharmacodynamics bacterial susceptibility and clinical efficacy [O] . A R H van Zanten, M Oudijk, M K E Nohlmans-Paulssen, 2007

机译：慢性阻塞性肺疾病和呼吸道感染患者的头孢噻肟连续或间歇给药：药代动力学/药效学细菌敏感性和临床疗效
7. Continuous vs. intermittent cefotaxime administration in patients with chronic obstructive pulmonary disease and respiratory tract infections: pharmacokinetics/pharmacodynamics, bacterial susceptibility and clinical efficacy [O] . van Zanten, A R H, Oudijk, M, Nohlmans-Paulssen, M K E, 2007

机译：慢性阻塞性肺疾病和呼吸道感染患者的头孢噻肟连续或间歇给药：药代动力学/药效学，细菌敏感性和临床疗效

Effect of Respiratory Tract Disease on Pharmacokinetics of Tilmicosin in Rats

摘要

著录项

相似文献

相关主题

期刊订阅