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首页> 外文期刊>Biology Open >Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila
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Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila

机译：平面细胞极性：Dachsous / Fat系统对果蝇的胚胎和幼虫阶段有不同的贡献

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摘要

The epidermal patterns of all three larval instars (L1–L3) of Drosophila are made by one unchanging set of cells. The seven rows of cuticular denticles of all larval stages are consistently planar polarised, some pointing forwards, others backwards. In L1 all the predenticles originate at the back of the cells but, in L2 and L3, they form at the front or the back of the cell depending on the polarity of the forthcoming denticles. We find that, to polarise all rows, the Dachsous/Fat system is differentially utilised; in L1 it is active in the placement of the actin-based predenticles but is not crucial for the final orientation of the cuticular denticles, in L2 and L3 it is needed for placement and polarity. We find Four-jointed to be strongly expressed in the tendon cells and show how this might explain the orientation of all seven rows. Unexpectedly, we find that L3 that lack Dachsous differ from larvae lacking Fat and we present evidence that this is due to differently mislocalised Dachs. We make some progress in understanding how Dachs contributes to phenotypes of wildtype and mutant larvae and adults.
机译：果蝇的所有三个幼虫龄期（L1-L3）的表皮模式是由一组不变的细胞组成的。所有幼体阶段的七排表皮细齿始终是平面极化的，有些指向前方，有些指向后。在L1中，所有前牙都起源于细胞的背面，而在L2和L3中，它们取决于即将形成的齿状体的极性而形成在细胞的正面或背面。我们发现，为了极化所有行，Dachsous / Fat系统被不同地利用。在L1中，它在基于肌动蛋白的前牙的放置中很活跃，但对于表皮齿状体的最终取向并不重要，在L2和L3中，它对于放置和极性是必需的。我们发现四接头在肌腱细胞中强烈表达，并表明这可能解释所有七行的方向。出乎意料的是，我们发现缺少Dachsous的L3与缺少脂肪的幼虫有所不同，并且我们提供的证据表明这是由于Dachs定位错误造成的。我们在了解Dachs如何对野生型和突变幼虫以及成年表型做出贡献方面取得了一些进展。

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