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首页> 外文期刊>Development >Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat.
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Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat.

机译：平面细胞极性：果蝇中幼虫树突的方向似乎取决于Dachsous和Fat的梯度。

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摘要

The larval ventral belts of Drosophila consist of six to seven rows of denticles that are oriented, some pointing forwards, some backwards. We present evidence that denticle orientation is determined almost entirely by Dachsous and Fat, one of two planar cell polarity systems. If we change the distribution of Dachsous we can alter the polarity of denticles. We suggest that the orientation of the individual denticle rows, in both the anterior compartment (which mostly point backwards) and the posterior compartment (which point forwards), is determined by the opposing slopes of a Dachsous/Fat gradient. We show, by altering the concentration gradients of Dachsous during development, that we can change the polarity of the denticles made by larval cells as they progress between the first and third larval instars without mitosis.
机译：果蝇的幼虫腹带由六到七排细齿组成，这些细齿定向，有些指向前方，有些指向后方。我们提供的证据表明，牙托的方向几乎完全由Dachsous和Fat（两个平面细胞极性系统之一）决定。如果我们改变Dachsous的分布，我们可以改变齿状体的极性。我们建议，在前房（大多指向后方）和后房（指向前方）中，各个齿列的方向取决于Dachsous / Fat梯度的相对斜率。我们显示，通过在发育过程中改变Dachsous的浓度梯度，我们可以改变幼虫细胞在第一和第三只幼虫龄之间前进而没有有丝分裂的过程中所形成的树突的极性。

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