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首页> 外文期刊>Biology Open >The constant beat: cardiomyocytes adapt their forces by equal contraction upon environmental stiffening
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The constant beat: cardiomyocytes adapt their forces by equal contraction upon environmental stiffening

机译：恒定搏动：心肌细胞在环境变硬时通过相等的收缩来适应其力量

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摘要

Cardiomyocytes are responsible for the permanent blood flow by coordinated heart contractions. This vital function is accomplished over a long period of time with almost the same performance, although heart properties, as its elasticity, change drastically upon aging or as a result of diseases like myocardial infarction. In this paper we have analyzed late rat embryonic heart muscle cells' morphology, sarcomere/costamere formation and force generation patterns on substrates of various elasticities ranging from ～1 to 500?kPa, which covers physiological and pathological heart stiffnesses. Furthermore, adhesion behaviour, as well as single myofibril/sarcomere contraction patterns, was characterized with high spatial resolution in the range of physiological stiffnesses (15?kPa to 90?kPa). Here, sarcomere units generate an almost stable contraction of ～4%. On stiffened substrates the contraction amplitude remains stable, which in turn leads to increased force levels allowing cells to adapt almost instantaneously to changing environmental stiffness. Furthermore, our data strongly indicate specific adhesion to flat substrates via both costameric and focal adhesions. The general appearance of the contractile and adhesion apparatus remains almost unaffected by substrate stiffness.
机译：心肌细胞通过协调的心脏收缩负责永久性血液流动。尽管随着年龄的增长或诸如心肌梗塞等疾病的发生，心脏的属性（如弹性）会急剧变化，但这项重要功能却可以在很长一段时间内以几乎相同的性能完成。在本文中，我们分析了后期大鼠胚胎心肌细胞的形态，肌节/肋节肌的形成以及在弹性范围从〜1至500？kPa的底物上的力生成模式，涵盖了生理和病理学上的心脏僵硬。此外，在生理刚度范围内（15？kPa至90？kPa），具有高空间分辨率的特点是粘附行为以及单一的肌原纤维/肌小节收缩模式。在这里，肌节单位产生约4％的几乎稳定的收缩。在硬化的基材上，收缩幅度保持稳定，这反过来导致增加的作用力水平，使细胞几乎瞬间适应变化的环境刚度。此外，我们的数据强烈表明通过肋胶和粘着剂对平坦基材的特定粘附力。收缩和粘附设备的总体外观几乎不受基材刚度的影响。

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