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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Serum Cytokine Responses during Acute Human Granulocytic Ehrlichiosis
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Serum Cytokine Responses during Acute Human Granulocytic Ehrlichiosis

机译：急性人类粒细胞埃希氏病期间的血清细胞因子反应

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Human granulocytic ehrlichiosis (HGE) is caused by obligate intracellular bacteria in the Ehrlichia phagocytophilagroup. The disease ranges from subclinical to fatal. We speculated that cell-mediated immunity would be important for recovery from and potentially in the clinical manifestations of HGE; thus, serum tumor necrosis factor alpha (TNF-α), interleukin 1β (IL-1β), gamma interferon (IFN-γ), IL-10, and IL-4 concentrations were studied. IFN-γ (1,035 ± 235 pg/ml [mean ± standard error of the mean]) and IL-10 (118 ± 46 pg/ml) concentrations were elevated in acute-phase sera versus convalescent sera and normal subjects (P?≤?0.013 and P?≤?0.018, respectively). TNF-α, IL-1β, and IL-4 levels were not elevated. Cytokine levels in severely and mildly affected patients were not different. HGE leads to induction of IFN-γ-dominated cell-mediated immunity associated with clinical manifestations, recovery from infection, or both.
机译：人粒细胞埃希氏菌病（HGE）是由吞噬埃希氏菌（Ehrlichia phagocytophila）组中的专性细胞内细菌引起的。该病范围从亚临床到致命。我们推测，细胞介导的免疫对于HGE的恢复以及在HGE的临床表现中具有重要意义。因此，研究了血清肿瘤坏死因子α（TNF-α），白介素1β（IL-1β），γ干扰素（IFN-γ），IL-10和IL-4的浓度。急性期血清与恢复期血清和正常人相比，IFN-γ（1,035±235 pg / ml [平均值±平均值的标准误差]）和IL-10（118±46 pg / ml）的浓度升高（ P ≤≤0.013和 P ≤≤0.018）。 TNF-α，IL-1β和IL-4水平未升高。重度和轻度患者的细胞因子水平没有差异。 HGE导致与临床表现，感染恢复或两者相关的IFN-γ主导的细胞介导的免疫反应。

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