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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Immunohematological Reference Ranges for Adult Ethiopians
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Immunohematological Reference Ranges for Adult Ethiopians

机译：成人埃塞俄比亚人的免疫血液学参考范围

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A cross-sectional survey was carried out with 485 healthy working adult Ethiopians who are participating in a cohort study on the progression of human immunodeficiency virus type 1 (HIV-1) infection to establish hematological reference ranges for adult HIV-negative Ethiopians. In addition, enumeration of absolute numbers and percentages of leukocyte subsets was performed for 142 randomly selected HIV-negative individuals. Immunological results were compared to those of 1,356 healthy HIV-negative Dutch blood donor controls. Immunohematological mean values, medians, and 95th percentile reference ranges were established. Mean values were as follows: leukocyte (WBC) counts, 6.1 × 109/liter (both genders); erythrocyte counts, 5.1 × 1012/liter (males) and 4.5 × 1012/liter (females); hemoglobin, 16.1 (male) and 14.3 (female) g/dl; hematocrit, 48.3% (male) and 42.0% (female); platelets, 205 × 109/liter (both genders); monocytes, 343/μl; granulocytes, 3,057/μl; lymphocytes, 1,857/μl; CD4 T cells, 775/μl; CD8 T cells, 747/μl; CD4/CD8 T-cell ratio, 1.2; T cells, 1,555/μl; B cells, 191/μl; and NK cells, 250/μl. The major conclusions follow. (i) The WBC and platelet values of healthy HIV-negative Ethiopians are lower than the adopted reference values of Ethiopia. (ii) The absolute CD4 T-cell counts of healthy HIV-negative Ethiopians are considerably lower than those of the Dutch controls, while the opposite is true for the absolute CD8 T-cell counts. This results in a significantly reduced CD4/CD8 T-cell ratio for healthy Ethiopians, compared to the ratio for Dutch controls.
机译：对参与研究人类免疫缺陷病毒1型（HIV-1）感染进展的队列研究的485名健康工作的成人埃塞俄比亚人进行了一项横断面调查，以确定成人HIV阴性埃塞俄比亚人的血液学参考范围。此外，对142个随机选择的HIV阴性个体进行了白细胞亚群绝对数和百分比的计数。免疫结果与1356例健康的HIV阴性荷兰献血者对照进行了比较。建立了免疫血液学的平均值，中位数和第95个百分点参考范围。平均值如下：白细胞（WBC）计数为6.1×10 9 /升（男女）;红细胞计数：5.1×10 12 /升（男性）和4.5×10 12 /升（女性）;血红蛋白，16.1（男性）和14.3（女性）g / dl;血细胞比容，男性为48.3％，女性为42.0％;血小板，每公升205×10 9 （男女）;单核细胞343 /μl;粒细胞3057 /μl;淋巴细胞1,857 /μl; CD4 T细胞，775 /μl; CD8 T细胞，747 /μl; CD4 / CD8 T细胞比率为1.2; T细胞，1,555 /μl; B细胞，191 /μl;和NK细胞，250 /μl。主要结论如下。 （i）健康的艾滋病毒阴性埃塞俄比亚人的白细胞和血小板值低于埃塞俄比亚采用的参考值。 （ii）健康的HIV阴性埃塞俄比亚人的CD4 T细胞绝对计数远低于荷兰对照，而CD8 T细胞绝对计数则相反。与埃塞俄比亚人的比率相比，健康的埃塞俄比亚人的CD4 / CD8 T细胞比率显着降低。

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