Bioactive tumor necrosis factor in the sputa of cystic fibrosis patients.

N Kelly; S Clee; B Nakielna

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Bioactive tumor necrosis factor in the sputa of cystic fibrosis patients.

机译：囊性纤维化患者痰中的生物活性肿瘤坏死因子。

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Eighty sputum samples from 37 cystic fibrosis patients were assayed for tumor necrosis factor alpha (TNF-alpha) in the L929 bioactivity assay. In addition, the presence of TNF-alpha-specific mRNA in the sputum was determined by using TNF-alpha-specific DNA probes in a PCR amplification step after reverse transcription of the mRNA to cDNA. Bioactive TNF-alpha was detected in 69 (86%) of the 80 sputum samples tested and, on at least one occasion, in 35 (95%) of the 37 cystic fibrosis patients sampled. The highest levels of TNF-alpha were observed in sputa obtained from patients presenting with an exacerbation of their disease.

机译：在L929生物活性测定中，对37位囊性纤维化患者的80份痰标本中的肿瘤坏死因子α（TNF-alpha）进行了测定。另外，在将mRNA逆转录成cDNA后，通过在PCR扩增步骤中使用TNF-α特异性DNA探针来确定痰中TNF-α特异性mRNA的存在。在80个痰液样本中有69个（86％）检测到了生物活性TNF-α，并且在37个囊性纤维化患者中至少有35个（95％）检测到了生物活性TNF-α。从患有疾病加重的患者的痰中观察到最高水平的TNF-α。

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《Clinical and diagnostic laboratory immunology》 |1995年第4期|共4页
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N Kelly; S Clee; B Nakielna;
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1. Tumor necrosis factor-α in airway secretions from cystic fibrosis patients upregulate endothelial adhesion molecules and induce airway epithelial cell apoptosis: Implications for cystic fibrosis lung disease [J] . MitolaS., SorbelloV., PonteE., International journal of immunopathology and pharmacology. . 2008,第4期

机译：囊性纤维化患者气道分泌物中的肿瘤坏死因子-α上调内皮粘附分子并诱导气道上皮细胞凋亡：对囊性纤维化肺病的意义
2. A novel chromogenic medium for isolation of Pseudomonas aeruginosa from the sputa of cystic fibrosis patients. [J] . Laine L, Perry JD, Lee J, Journal of cystic fibrosis: official journal of the European Cystic Fibrosis Society . 2009,第2期

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3. Association between transcript levels of the Pseudomonas aeruginosa regA, regB, and toxA genes in sputa of cystic fibrosis patients. [J] . T L Raivio, E E Ujack, H R Rabin, Infection and immunity . 1994,第8期

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机译：囊性纤维化跨膜电导调节剂基因突变引起'黑色'颜料胆结石形成：来自小鼠模型的新见解，以及对囊性纤维化治疗干预的影响
5. Factors shed by breast tumor cells, tumor necrosis factor alpha converting enzyme activities, and the generation of pro-tumor macrophages. [D] . Rego, Stephen Lee. 2013

机译：乳腺肿瘤细胞脱落的因子，肿瘤坏死因子α转换酶的活性以及促肿瘤巨噬细胞的产生。
6. Bioactive tumor necrosis factor in the sputa of cystic fibrosis patients. [O] . N Kelly, S Clee, B Nakielna 1995

机译：囊性纤维化患者痰中的生物活性肿瘤坏死因子。
7. The tumor necrosis factor α (-308 A/G) polymorphism is associated with cystic fibrosis in Mexican patients. [O] . Celia N Sanchez-Dominguez, Miguel A Reyes-Lopez, Adriana Bustamante, 2014

机译：肿瘤坏死因子α（-308 a / G）多态性与墨西哥患者的囊性纤维化有关。

Bioactive tumor necrosis factor in the sputa of cystic fibrosis patients.

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