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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Grape Seed Extract Activates Th1 Cells In Vitro
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Grape Seed Extract Activates Th1 Cells In Vitro

机译：葡萄籽提取物可体外激活Th1细胞

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Although flavonoids manifest a diverse range of biological activities, including antitumor and antiviral effects, the molecular mechanisms underlying these activities await elucidation. We hypothesize that the flavonoid constituents of a proprietary grape seed extract (GSE) that contains procyandins exert significant antiviral and antitumor effects, by inducing production of the Th1-derived cytokine gamma interferon (IFN-γ) by peripheral blood mononuclear cells) from healthy donors. Our results show that GSE significantly induced the transcription of IFN-γ mRNA as demonstrated by reverse transcription-PCR but had no effect on the Th2-derived cytokine interleukin-6. The enhancing effect of GSE on IFN-γ expression was further supported by a concomitant increase in the number of cells with intracytoplasmic IFN-γ as well as the synthesis and secretion of IFN-γ. Our results demonstrate that the potentially beneficial immunostimulatory effects of GSE may be mediated through the induction of IFN-γ.
机译：尽管类黄酮表现出各种各样的生物活性，包括抗肿瘤和抗病毒作用，但这些活性的分子机制尚待阐明。我们假设包含原花青素的专有葡萄籽提取物（GSE）中的类黄酮成分通过诱导健康捐献者产生的Th1衍生的细胞因子γ干扰素（IFN-γ）产生了显着的抗病毒和抗肿瘤作用。 。我们的结果表明，如逆转录PCR所示，GSE显着诱导IFN-γmRNA的转录，但对Th2衍生的细胞因子白介素6没有影响。 GSE对IFN-γ表达的增强作用进一步得到支持，同时伴随胞浆内IFN-γ的细胞数量增加以及IFN-γ的合成和分泌。我们的结果表明，GSE潜在有益的免疫刺激作用可能是通过诱导IFN-γ介导的。

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