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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Reduction of Influenza Virus Titer and Protection against Influenza Virus Infection in Infant Mice Fed Lactobacillus casei Shirota
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Reduction of Influenza Virus Titer and Protection against Influenza Virus Infection in Infant Mice Fed Lactobacillus casei Shirota

机译：减少饲喂干酪乳杆菌Shirota的小鼠的流感病毒滴度和预防流感病毒感染

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摘要

We investigated whether oral administration of Lactobacillus casei strain Shirota to neonatal and infant mice ameliorates influenza virus (IFV) infection in the upper respiratory tract and protects against influenza infection. In a model of upper respiratory IFV infection, the titer of virus in the nasal washings of infant mice administered L. casei Shirota (L. casei Shirota group) was significantly (P < 0.05) lower than that in infant mice administered saline (control group) (102.48 ± 100.31 and 102.78 ± 100.4, respectively). Further, the survival rate of the L. casei Shirota group was significantly (P < 0.05) higher than that of the control group (14.3 versus 40.0%). One day after infection, pulmonary NK cell activity and interleukin-12 production by mediastinal lymph node cells of mice in the L. casei Shirota group were significantly greater than those of mice in the control group. These findings suggest that oral administration of L. casei Shirota activates the immature immune system of neonatal and infant mice and protects against IFV infection. Therefore, oral administration of L. casei Shirota may accelerate the innate immune response of the respiratory tract and protect against various respiratory infections in neonates, infants, and children, a high risk group for viral and bacterial infections.
机译：我们调查了对新生小鼠和婴儿小鼠口服干酪乳杆菌Shirota菌株是否能改善上呼吸道的流感病毒（IFV）感染并预防流感感染。在上呼吸道IFV感染模型中，给予 L的婴儿小鼠鼻洗液中的病毒滴度。 Casei Shirota（ L。casei Shirota组）显着（ P <0.05）比注射生理盐水的婴儿小鼠（对照组）低（10 2.48 ±10 0.31 和10 2.78 ±10 0.4 ）。此外， L的存活率。 Casei Shirota组显着（ P <0.05）高于对照组（14.3对40.0％）。感染后一天， L小鼠的纵隔淋巴结细胞产生了肺NK细胞活性和白介素12的产生。 Casei Shirota组显着大于对照组的小鼠。这些发现表明口服 L。 casei Shirota激活新生小鼠和婴儿小鼠的免疫系统，并预防IFV感染。因此，口服 L。 casei Shirota可能会加速呼吸道的先天免疫反应，并防止新生儿，婴儿和儿童（病毒和细菌感染的高危人群）遭受各种呼吸道感染。

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